Consequences of coronavirus infections for primitive and mature hematopoietic cells: new insights and why it matters.
Consequences of coronavirus infections for primitive and mature hematopoietic cells: new insights and why it matters.
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DOI：
10.1097/moh.0000000000000645
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发表时间：
2021-07-01
影响因子：
3.2
通讯作者：
Broxmeyer HE
中科院分区：
文献类型：
--
作者：
Ropa J;Trinh T;Aljoufi A;Broxmeyer HE
在近代史上，曾三次在人类中爆发贝塔冠状病毒感染，最近一次爆发的SARS-CoV-2(导致新冠肺炎)导致200多万人死亡，死亡人数迅速上升。关于受冠状病毒感染影响的宿主细胞和组织，包括造血系统，仍有许多未知之处。在这里，我们讨论最近的发现，检查冠状病毒感染或暴露对造血细胞的影响，以及这些影响的临床意义。最近的研究集中在SARS-CoV-2，表明造血干细胞(HSCs)、祖细胞(HPC)和成熟的免疫细胞可能对感染易感，并因暴露于SARS-CoV-2 Spike蛋白而影响功能。这些发现对于我们在这里讨论的新冠肺炎和其他冠状病毒引起的疾病引起的血液学并发症具有重要的意义。冠状病毒感染有时会导致患者的血液系统并发症，而这些血液系统并发症与较差的预后有关。这些血液学并发症可能是冠状病毒直接感染或影响原始造血细胞或成熟免疫细胞、间接作用于这些细胞或其组合所致。重要的是要了解血液学并发症是如何发生的，以便寻求新的治疗方法来改善患者的预后。
In recent history there have been three outbreaks of betacoronavirus infections in humans, with the most recent SARS-CoV-2 (causing COVID-19) outbreak leading to over two million deaths, with a rapidly rising death toll. Much remains unknown about host cells and tissues affected by coronavirus infections, including the hematopoietic system. Here we discuss the recent findings examining effects that coronavirus infection or exposure has on hematopoietic cells and the clinical implications for these effects. Recent studies have centered on SARS-CoV-2, demonstrating that hematopoietic stem (HSCs) and progenitor cells (HPCs) and mature immune cells may be susceptible to infection and are impacted functionally by exposure to SARS-CoV-2 Spike protein. These findings have important implications regarding hematologic complications arising from COVID-19 and other coronavirus induced disease, which we discuss here. Infection with coronaviruses sometimes leads to hematologic complications in patients, and these hematologic complications are associated with poorer prognosis. These hematologic complications may be caused by coronavirus direct infection or impact on primitive hematopoietic cells or mature immune cells, by indirect effects on these cells, or by a combination thereof. It is important to understand how hematologic complications arise in order to seek new treatments to improve patient outcomes.