Review article: implications of vascular aging.
Review article: implications of vascular aging.
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DOI：
10.1213/ane.0b013e3182147e3c
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发表时间：
2011-05
影响因子：
5.7
通讯作者：
Nyhan D
中科院分区：
文献类型：
--
作者：
Barodka VM;Joshi BL;Berkowitz DE;Hogue CW Jr;Nyhan D
实足年龄是心血管疾病发展的一个公认的危险因素。然而，随着年龄的增长，血管系统中积累的变化是高度可变的。现在越来越多的人认识到，在预测不良心血管结局方面，血管健康指数比年龄本身更可靠。这些与年龄相关的血管变化的累积变化是多种遗传和环境因素的函数。在这篇综述中，我们强调了一些病理生理机制的特点血管老化表型。此外，我们提供了一个概述的关键结果的研究，解决这些血管健康指数的价值一般，并讨论围手术期心血管结局的潜在影响。
Chronological age is a well established risk factor for the development of cardiovascular diseases. The changes that accumulate in the vasculature with age, though, are highly variable. It is now increasingly recognized that indices of vascular health are more reliable than age per se in predicting adverse cardiovascular outcomes. The variation in the accrual of these age-related vascular changes is a function of multiple genetic and environmental factors. In this review, we highlight some of the pathophysiological mechanisms that characterize the vascular aging phenotype. Furthermore, we provide an overview of the key outcome studies that address the value of these vascular health indices in general and discuss potential effects on perioperative cardiovascular outcomes.