Cathepsin L is up-expressed in atherosclerotic lesion induced by shear stress
Cathepsin L is up-expressed in atherosclerotic lesion induced by shear stress
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组织蛋白酶 L 在剪切应力诱导的动脉粥样硬化病变中表达上调
DOI：
10.1109/bmei.2011.6098521
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发表时间：
2011-12
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
组织蛋白酶L是一种剪切敏感的基质蛋白酶。然而，没有可用的体内证据。本研究用硅胶环治疗10只家兔左颈动脉直段狭窄，并喂饲高脂/高胆固醇饲料4周。数值模拟表明，狭窄近端和远端附近的血流受到显着干扰。环近端剪应力明显增大（>6Pa），环远端剪应力减小（0 ~ 0.3Pa）。4周时狭窄近端和远端均可见病变，但近端病变中巨噬细胞和脂质沉积较多。组织蛋白酶L在近端病变中高表达，而在远端病变中表达较少。综合起来，剪切应力归因于动脉粥样硬化。高剪切应力诱导具有易损斑块表型的较大病变，而低剪切应力诱导稳定病变。组织蛋白酶L的差异表达可能与动脉粥样硬化病变的性质有关。
Cathepsin L has been implicated a shear-sensitive matrix protease. However, there was no in vivo evidence available. In this study, ten rabbits were treated with gel-silica loop to develop a defined local stenosis in left carotid arteries straight segment and fed with high fat/cholesterol diet for 4 weeks. Numerical simulation showed that blood flow was disturbed significantly at the immediate proximal and distal vicinity of stenosis. The shear stress in proximal part of ringer was obviously increased (>6Pa), while the shear stress in distal of ring was decreased (0∼0.3Pa). Lesions were observed in both proximal and distal of the stenosis at the end of 4 weeks, however, the lesion from proximal had more macrophage cells and lipid deposition. In proximal lesions, cathepsin L was highly expressed, whereas less cathepsin L was detected in distal lesion. Taken together, shear stress attributed to atherosclerosis. High shear stress induces larger lesions with a vulnerable plaque phenotype, whereas low shear stress induces stable lesions. The differentia expression of cathepsin L may contribute to the feature of atherosclerotic lesion.
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影响因子：
37.8
作者：
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通讯作者：
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影响因子：
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DOI：
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