Influence of a chemically defined diet on the composition of serum and urine.
Influence of a chemically defined diet on the composition of serum and urine.
复制标题
化学限定饮食对血清和尿液成分的影响。
DOI：
10.1093/clinchem/17.8.765
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发表时间：
1971
影响因子：
9.3
通讯作者：
P. Goldman
中科院分区：
文献类型：
--
作者：
D. Young;J. A. Epley;P. Goldman
我们研究了摄取化学定义饮食对五名正常志愿者血清和尿液成分的影响。这种饮食被认为满足了人类所有的营养需求，导致了血清胆固醇和尿素氮的降低，以及血清磷、尿酸和肌酐的增加。与随机饮食相比，尿肌酐没有变化，但尿电解质、尿素和尿酸下降到一个新的稳定值，这是在四天后实现的。高分辨率技术已经被用来测量尿液中含有碳水化合物的成分，以及那些可以通过紫外线吸收或与吲哚的反应来检测到的成分。这些尿液成分的数量在四天内受到化学饮食的影响，但即使到了这个时候，可归因于随机饮食的所有化合物也可能还没有完全消除。许多尿液成分在受试者进行简化饮食期间仍然存在，目前已初步确定。
We have studied the effects of ingestion of a chemically defined diet on the constituents of serum and urine of five normal volunteers. The diet, believed to meet all human nutritional requirements, caused a decrease in serum cholesterol and urea nitrogen and an increase in serum phosphate, uric acid, and creatinine. Urinary creatinine is unchanged from that of a random diet but urinary electrolytes, urea, and uric acid decrease to a new stable value, which is achieved after four days. High-resolution techniques have been used to measure the carbohydrate-containing constituents of urine and those that can be detected by their ultraviolet absorbance or their reaction with ninhydrin. A considerable decrease in the number of these urinary constituents is effected by the chemical diet within four days, but even by this time all compounds attributable to the random diet may not have been completely eliminated. Many urinary components that persist while the subjects are on the simplified diet have been tentatively identified.