Cross-sectional study of psychiatric comorbidities in patients with atopic dermatitis and nonatopic eczema, urticaria, and psoriasis
Cross-sectional study of psychiatric comorbidities in patients with atopic dermatitis and nonatopic eczema, urticaria, and psoriasis
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DOI：
10.2147/ndt.s191509
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发表时间：
2019-01-01
影响因子：
3.2
通讯作者：
Lew, Bark-Lynn
中科院分区：
文献类型：
--
作者：
Ahn, Hye-Jin;Shin, Min Kyung;Lew, Bark-Lynn
背景：近期数据表明，抑郁症与慢性皮肤病相关，包括特应性皮炎（AD）、荨麻疹和银屑病。本研究比较了韩国特应性皮炎患者与非特应性湿疹、荨麻疹和银屑病患者的精神疾病情况。
方法：采用横断面研究设计，分析2015年韩国国民健康保险研究数据库的数据，该数据库对42641名特应性皮炎患者和139486名非特应性皮炎（非特应性湿疹、荨麻疹和银屑病）患者（男性103938名，女性78189名）按年龄分类：婴儿，0 - 3岁；幼儿期，4 - 8岁；儿童晚期，9 - 12岁；青少年，13 - 18岁；成年人，19 - 64岁；老年人，65岁以上。进行了多元逻辑回归分析，并计算了有特应性皮炎和无特应性皮炎患者的各种精神疾病——注意缺陷/多动障碍（ADHD）、自闭症谱系障碍（ASD）、品行障碍、抑郁症、焦虑症、自杀意念、精神分裂症和睡眠障碍的比值比（OR）。
结果：特应性皮炎患者和非特应性皮炎患者之间抑郁症的发病率没有显著差异。重度特应性皮炎显示出较高的抑郁症比值比（中度特应性皮炎OR = 1.75；重度特应性皮炎OR = 3.15，P（此处似乎内容不完整）
Background: Recent data suggest depression has been linked to chronic skin diseases, including atopic dermatitis (AD), urticaria, and psoriasis. This study compared mental illnesses in patients with AD with those of patients with nonatopic eczema, urticaria, and psoriasis in Korea.Methods: A cross-sectional study design was used, analyzing data from the 2015 Korean National Health Insurance Research Database, a survey of 42,641 AD and 139,486 non-AD (nonatopic eczema, urticaria, and psoriasis) patients (103,938 males, 78,189 females) classified by age: infant, aged 0-3 years; early childhood, aged 4-8 years; late childhood, aged 9-12 years; adolescent, aged 13-18 years; adult, aged 19-64 years; elderly, aged above 65 years. Multiple logistic regression analysis was performed, and the odds ratio (OR) of various mental illnesses - attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), conduct disorder, depression, anxiety, suicidal ideation, schizophrenia, and sleep disorder - were calculated for patients with and without AD.Results: The incidence of depression was not significantly different between AD and non-AD patients. Severe AD showed a high OR of depression (moderate AD OR=1.75; severe AD OR=3.15, P