One-step preparation of chitosan solid nanoparticles by electrospray deposition
One-step preparation of chitosan solid nanoparticles by electrospray deposition
复制标题
DOI：
10.1016/j.ijpharm.2010.07.007
复制
发表时间：
2010-09-15
影响因子：
5.8
通讯作者：
Kawakami, Kohsaku
中科院分区：
文献类型：
--
作者：
Zhang, Shaoling;Kawakami, Kohsaku
以壳聚糖/醋酸溶液为原料，采用电喷雾一步法制备了固体微米和纳米颗粒。考察了不同溶液性质和工艺参数对颗粒形成的影响。溶液粘度和电导率是影响电喷雾行为的最重要因素，即只有当溶液粘度高和/或电导率低时，才能获得稳定的电喷雾。降低醋酸浓度、壳聚糖浓度和/或流速可以得到较小的颗粒。此外，乙醇的加入降低了溶液的电导率，增加了溶液的粘度，从而有效地稳定了电喷雾。通过对溶液和操作参数的优化，壳聚糖颗粒的平均粒径减小到124 nm，这表明电喷雾技术在制备口服和肺部给药系统的固体微米和纳米粒方面具有很好的应用前景。(C)2010爱思唯尔B.V.保留所有权利。
Solid micro- and nanoparticles were prepared from chitosan/acetic acid solution in one-step by the electrospray procedure. The effects of various solution properties and processing parameters on particle formation were investigated. Solution viscosity and conductivity were the most important factors affecting electrospray behavior, i.e., stable electrospray was achieved only when viscosity was high and/or conductivity was low. Smaller particles could be obtained by decreasing acetic acid concentration, chitosan concentration, and/or flow rate. Furthermore, addition of ethanol could effectively stabilize the electrospray by decreasing the solution conductivity and increasing the solution viscosity. By optimizing the solution and operation parameters, the average diameter of the chitosan particles was reduced down to 124 nm, suggesting that electrospray is promising in producing solid micro- and nanoparticles for oral and pulmonary drug delivery systems. (C) 2010 Elsevier B.V. All rights reserved.