POTENTIATION OF ANTI-TUMOR EFFECT OF CYCLOPHOSPHAMIDE AND HYDRAZINE SULFATE BY TREATMENT WITH THE ANTI-DIABETIC AGENT, 1-PHENYLETHYLBIGUANIDE (PHENFORMIN)
POTENTIATION OF ANTI-TUMOR EFFECT OF CYCLOPHOSPHAMIDE AND HYDRAZINE SULFATE BY TREATMENT WITH THE ANTI-DIABETIC AGENT, 1-PHENYLETHYLBIGUANIDE (PHENFORMIN)
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DOI：
10.1016/s0304-3835(79)80066-x
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发表时间：
1979-01-01
期刊：
影响因子：
9.7
通讯作者：
ANISIMOV, VN
中科院分区：
文献类型：
--
作者：
DILMAN, VM;ANISIMOV, VN
1 - 苯乙双胍（苯福明）以2毫克/天的剂量口服给予小鼠，增强了环磷酰胺对小鼠可移植性宫颈鳞状细胞癌[SCC]、肝癌 - 22a和Lewis肺癌的抗肿瘤作用，但没有改变环磷酰胺对肉瘤 - 180和白血病L - 1210的作用。以5毫克/天的剂量给移植了Walker 256癌的大鼠口服苯福明，增强了硫酸肼的抗肿瘤作用。
1-Phenylethylbiguanide (phenformin) administered orally to mice at a dose of 2 mg/day potentiated the antitumor effect of cyclophosphamide on mouse transplantable squamous cell cervical carcinoma [SCC], hepatoma-22a and Lewis lung tumor, but did not alter the effect of cyclophosphamide on sarcoma-180 and leukemia L-1210. Oral administration of phenformin (5 mg/day) to rats with transplanted Walker 256 carcinoma enhanced the antitumor effect of hydrazine sulfate.