Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.
Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.
复制标题
DOI：
10.1038/bjc.1983.247
复制
发表时间：
1983-11
影响因子：
8.8
通讯作者：
Moran, F
中科院分区：
文献类型：
--
作者：
Ahmedzai, S;Carlyle, D L;Calder, I T;Moran, F
在一项双盲交叉研究中，34名肺癌患者接受了环磷酰胺、阿霉素和依托泊苷为期3天的化疗，对合成大麻素纳比隆和丙氯哌嗪进行了比较。纳贝酮组患者恶心、呕吐症状评分明显优于对照组(P<0.05)。服用纳比隆的患者呕吐次数较少(P=0.05)，呕吐次数较少(P<0.05)；服用纳比隆的患者均不需要额外的肠外止吐。更多的患者选择纳比隆止吐(P<0.005)。纳贝隆常见的不良反应是嗜睡(57%)、姿势头晕(35%)和头晕(18%)。有14%的人感到欣喜若狂，7%的人感觉到了高度兴奋。纳比隆患者第1天的直立收缩压较低(P=0.05)，但只有7%的患者存在体位性低血压的主要问题。纳贝酮是一种有效的口服止吐药物，适用于中等毒性的化疗，但其副作用的范围和不可预测性值得谨慎使用。
Nabilone, a synthetic cannabinoid, and Prochlorperazine were compared in a double-blind crossover study of 34 patients with lung cancer undergoing a 3-day schedule of chemotherapy with Cyclophosphamide, Adriamycin and Etoposide. Symptom scores were significantly better for patients on nabilone for nausea, retching and vomiting (P less than 0.05). Fewer subjects vomited with nabilone (P = 0.05) and the number of vomiting episodes was lower (P less than 0.05); no patients on nabilone required additional parenteral anti-emetic. More patients preferred nabilone for anti-emetic control (P less than 0.005). Adverse effects common with nabilone were drowsiness (57%), postural dizziness (35%) and lightheadedness (18%). Euphoria was seen in 14% and a "high" in 7%. Erect systolic blood pressure was lower in nabilone patients on Day 1 (P = 0.05) but postural hypotension was a major problem in only 7%. Nabilone is an effective oral anti-emetic drug for moderately toxic chemotherapy, but the range and unpredictability of its side-effects warrant caution in its use.