Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children
Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children
复制标题
使用保存的干燥脐带对 UGT1A1 多态性进行遗传分析，以评估新生儿黄疸作为儿童自闭症谱系障碍危险因素的可能性
DOI：
10.1007/s10803-021-04941-w
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
他
中科院分区：
文献类型：
--
作者：
Horinouchi Tomoko;Maeyama Kaori;Nagai Masashi;Nishimura Mio;Kawasaki Yoko;Yoshioka Mieko;Takada Satoshi;Matsumoto Hisayuki;Nakamachi Yuji;Saegusa Jun;Fukushima Sachiyo;Fujioka Kazumichi;Nagase Hiroaki;Nozu Kandai;Iijima Kazumoto;Nishimura Noriyuki;他
新生儿黄疸已被认为是自闭症谱系障碍（ASD）的围产期危险因素。我们利用从保存的脐带中提取的DNA检测UGT 1A1多态性，以评估新生儿黄疸作为儿童ASD危险因素的可能性。总共有79名ASD儿童进行了UGT1A1 * 28（c. 41 - 40dup）、UGT 1A1 * 6（c.211 G> A）和UGT 1A1 * 27（c.686 C> A）。UGT 1A1 * 6（OR = 1.34，p = 0.26）和UGT 1A1 * 28（OR = 0.80，p = 0.54）等位基因频率以及UGT 1A1 * 28/* 6双倍型的患病率与对照组相比无显著性差异。在受试者中检测到NoUGT1A1 * 27等位基因。ASD症状评估评分与UGT 1A1 * 28/* 6/* 27基因型或UGT 1A1 * 28/* 6双体型无关。这些结果表明，新生儿黄疸与ASD无显著相关性。
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examinedUGT1A1polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped forUGT1A1*28(c.-41-40dup), UGT1A1*6(c.211 G > A), andUGT1A1*27(c.686 C > A). The allele frequency ofUGT1A1*6(OR = 1.34, p = 0.26) andUGT1A1*28(OR = 0.80, p = 0.54) and the prevalence ofUGT1A1*28/*6diplotypes did not differ significantly from those in the control population. NoUGT1A1*27allele was detected in the subjects. ASD symptom assessment scores were not associated withUGT1A1*28/*6/*27genotypes orUGT1A1*28/*6diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.