Slit coordinates cardiac morphogenesis in Drosophila
Slit coordinates cardiac morphogenesis in Drosophila
复制标题
DOI：
10.1016/j.ydbio.2006.01.027
复制
发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Jacobs, JR
中科院分区：
文献类型：
--
作者：
MacMullin, A;Jacobs, JR
狭缝是一种分泌的引导线索，从目标细胞和路标细胞传递排斥或吸引信号。在果蝇中，应答细胞表达三种Robo受体中的一种或多种。发育中的心脏细胞同时表达Slit和Robo2。这是首次报道机器人及其配体同时表达。在狭缝突变体中，心脏细胞排列、极化和均匀迁移被破坏。robo2突变体的心脏表型相似，迁移缺陷较少。在果蝇神经元生长锥的指导下，狭缝杂合子与robo杂合子之间存在表型相互作用，也与robo信号所需的基因存在表型相互作用。相比之下，在心脏中，slit与Robo2、Nck2和Disabled等机器人相关基因很少或没有表型相互作用。然而，与整合素基因及其配体（包括层粘连蛋白和胶原蛋白）和细胞内信使（包括Talin和ILK）存在强烈的表型相互作用。这表明Slit参与了心脏发育过程中的粘附或粘附信号传导。(c) 2006爱思唯尔公司版权所有。
Slit is a secreted guidance cue that conveys repellent or attractive signals from target and guidepost cells. In Drosophila, responsive cells express one or more of three Robo receptors. The cardial cells of the developing heart express both Slit and Robo2. This is the first report of coincident expression of a Robo and its ligand. In slit mutants, cardial cell alignment, polarization and uniform migration are disrupted. The heart phenotype of robo2 mutants is similar, with fewer migration defects. In the guidance of neuronal growth cones in Drosophila, there is a phenotypic interaction between slit and robo heterozygotes, and also with genes required for Robo signaling. In contrast, in the heart, slit has little or no phenotypic interaction with Robo-related genes, including Robo2, Nck2, and Disabled. However, there is a strong phenotypic interaction with Integrin genes and their ligands, including Laminin and Collagen, and intracellular messengers, including Talin and ILK. This indicates that Slit participates in adhesion or adhesion signaling during heart development. (c) 2006 Elsevier Inc. All rights reserved.