Neural responses to monetary incentives in major depression
Neural responses to monetary incentives in major depression
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DOI：
10.1016/j.biopsych.2007.07.023
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发表时间：
2008-04-01
影响因子：
10.6
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Knutson, Brian;Bhanji, Jamil P.;Gotlib, Ian H.
背景：对积极激励的反应性降低是重性抑郁症（MDD）的一个中心特征。在本研究中，我们比较了神经相关的金钱激励处理未服药的抑郁症患者和从未抑郁的对照subjects.Methods：14个目前抑郁症和12个从未抑郁的参与者进行功能磁共振成像，而参与了金钱激励延迟任务。在任务中，参与者被提示预期和响应迅速提出的目标，以获得或避免失去不同数量的money.Results：抑郁和从不抑郁的参与者没有不同的核神经元（NAcc）激活或在获得预期的情感或行为反应。然而，抑郁的参与者在预期收益增加的过程中表现出前扣带回激活增加，而从不抑郁的参与者在预期损失增加的过程中表现出前扣带回激活增加。抑郁的参与者还表现出对获得与非获得结果的歧视减少。结论：目前的研究结果表明，尽管未经药物治疗的抑郁个体有能力在获得预期期间经历积极的唤醒并招募NAcc激活，但他们也表现出前扣带皮质激活增加，这表明除了表现出对获得与非获得结果的歧视减少之外，在预期获得期间的冲突也增加了。
Background: Reduced responsiveness to positive incentives is a central feature of Major Depressive Disorder (MDD). In the present study, we compared neural correlates of monetary incentive processing in unmedicated depressed participants and never-depressed control subjects.Methods: Fourteen currently depressed and 12 never-depressed participants underwent functional magnetic resonance imaging while participating in a monetary incentive delay task. During the task, participants were cued to anticipate and respond to a rapidly presented target to gain or avoid losing varying amounts of money.Results: Depressed and never-depressed participants did not differ in nucleus accumbens (NAcc) activation or in affective or behavioral responses during gain anticipation. Depressed participants did, however, exhibit increasing anterior cingulate activation during anticipation of increasing gains, whereas never-depressed participants showed increasing anterior cingulate activation during anticipation of increasing loss. Depressed participants also showed reduced discrimination of gain versus nongain outcomes.Conclusions: The present findings indicate that although unmedicated depressed individuals have the capacity to experience positive arousal and recruit NAcc activation during gain anticipation, they also exhibit increased anterior cingulate cortex activation, suggestive of increased conflict during anticipation of gains, in addition to showing reduced discrimination of gain versus nongain outcomes.