Convergence of multiple mechanisms of steroid hormone action.
Convergence of multiple mechanisms of steroid hormone action.
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DOI：
10.1055/s-0032-1306343
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Anesetti G
中科院分区：
文献类型：
--
作者：
Mani SK;Mermelstein PG;Tetel MJ;Anesetti G
甾体激素调节多种生理过程，包括各种物种的发育、代谢和生殖。通常认为，这些生物学效应主要通过其与特定细胞内受体的结合介导，导致构象变化、二聚化和转录依赖性基因组作用的辅调节因子的募集（经典机制）。此外，对于它们的同源配体，细胞内类固醇受体也可以以“配体非依赖性”方式被包括神经递质在内的其他因子激活。最近的研究表明，快速的，非经典的类固醇效应涉及位于细胞膜上的胞核类固醇受体，其与细胞质激酶信号分子和G蛋白相互作用。目前的审查涉及各种机制，共同发挥作用，以综合的方式，以促进依赖于行动的中枢和交感神经系统。
Steroid hormones modulate a wide array of physiological processes including development, metabolism, and reproduction in various species. It is generally believed that these biological effects are predominantly mediated by their binding to specific intracellular receptors resulting in conformational change, dimerization, and recruitment of coregulators for transcription-dependent genomic actions (classical mechanism). In addition, to their cognate ligands, intracellular steroid receptors can also be activated in a “ligand-independent” manner by other factors including neurotransmitters. Recent studies indicate that rapid, nonclassical steroid effects involve extranuclear steroid receptors located at the membrane, which interact with cytoplasmic kinase signaling molecules and G-proteins. The current review deals with various mechanisms that function together in an integrated manner to promote hormone-dependent actions on the central and sympathetic nervous systems.
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