THE STRUCTURE OF INTERMEDIATE VASCULAR PATHWAYS IN THE SPLEEN OF RABBITS.
THE STRUCTURE OF INTERMEDIATE VASCULAR PATHWAYS IN THE SPLEEN OF RABBITS.
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兔子脾脏中间血管通路的结构。
DOI：
10.1002/aja.1001130106
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发表时间：
1963
影响因子：
--
通讯作者：
Leon Weiss
中科院分区：
文献类型：
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作者：
Leon Weiss
红髓和边缘区的主要功能可能是清除和修饰某些血管成分。受损的红细胞、老化的红细胞（韦斯，'62）、Foa-Kurloff细胞（Nadel，' 52）、胸腺淋巴细胞（Fichtelius，'60）、休克和冬眠中的粒细胞、血浆中的二氧化钍和其他胶体物质（韦斯，' 62）、内毒素是脾清除的元素的例子。在某些情况下，如休克动物的粒细胞和血浆二氧化钍，这些功能与肝脏，网状内皮系统的其他部分，甚至肺和肾共享。在其他情况下，由于FOB-Kurloff细胞和淋巴细胞在胸腺中产生，脾脏在隔离中的作用可能更具选择性。存在一些歧视：中度损伤的红细胞被脾选择性地从循环中除去;严重损伤的红细胞被肝和网状内皮系统作为一个整体除去（Jandl和Kaplan，′ 60; Winkelman，瓦格纳，McAfee和Mozley，′ 60）。一旦从血液中清除，被困的元素会遇到不同的命运。受损的红细胞被吞噬。淋巴细胞和单核细胞可以转化为浆细胞和巨噬细胞。其他细胞可能会保持不同的时间长度储存和重新进入循环，形态不变
It is likely that the major functions of the red pulp and marginal zone are clearance and modification of certain hemal elements. Damaged erythrocytes, aged erythrocytes (Weiss,'62), Foa-Kurloff cells (Nadel,'52), lymphocytes from the thymus (Fichtelius,'60), granulocytes in shock and in hibernation, thorium dioxide and other colloidal matter in plasma (Weiss,'62), endotoxin, are examples of elements cleared by the spleen. In some instances, as granulocytes of animals in shock and plasmal thorium dioxide, these functions are shared with the liver, other parts of the reticuloendothelial system, and even the lungs and kidneys. In other cases, as the FOB-Kurloff cell and lymphocytes produced in the thymus, the spleen's role in sequestration may be more selective. Nice discriminations exist: moderately damaged erythrocytes are selectively removed from the circulation by the spleen; severely damaged erythrocytes, by the liver and reticuloendothelial system as a whole (Jandl and Kaplan,'60; Winkelman, Wagner, McAfee and Mozley,'60). Once cleared from the blood, the trapped elements meet varied fates. Impaired erythrocytes are phagocytized. Lymphocytes and monocytes may undergo transformation into plasma cells and macrophages. Other cells may remain stored varying lengths of time and re-enter the circulation, morphologically unchanged