Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses
Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses
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DOI：
10.1136/mp.55.6.389
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发表时间：
2002-12-01
期刊：
影响因子：
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通讯作者：
Haddad, BR
中科院分区：
文献类型：
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作者：
Batanian, JR;Cavalli, LR;Haddad, BR
关于骨肉瘤的经典细胞遗传学和比较基因组杂交(CGH)数据已在文献中广泛报道。然而，14岁以下儿童骨肉瘤的研究病例数量仍然相对较少，本研究报告了4例3至13岁儿童骨肉瘤的新病例，通过经典细胞遗传学和CGH分析进行评估。所有病例均有克隆性染色体改变，包括1p11-13、1q11、4q27-33、6p23-25、6q16-25、7p13-22、7q11-36、11p10-15、11q23、17p11.2-13、21p11和21q11-22的结构重排。CGH分析显示，在1便士、4便士、17便士和21便士的经常性收益，在3季度和16便士的亏损。在1q11-23、6p21、8q13、8q21.3-24.2和17p有5个扩增位点。对这些数据进行了讨论，并与文献中的其他细胞遗传学报告进行了比较。
Classic cytogenetic and comparative genomic hybridisation (CGH) data on osteosarcomas have been reported extensively in the literature. However, the number of paediatric osteosarcoma cases studied below the age of 14 years remains relatively small, This study reports four new cases of paediatric osteosarcoma in patients aged 3 to 13 years, evaluated by classic cytogenetics and CGH analyses. Clonal chromosomal alterations were detected in all the cases and included structural rearrangements at 1p11-13, 1q11, 4q27-33, 6p23-25, 6q16-25, 7p13-22, 7q11-36, 11p10-15, 11q23, 17p11.2-13, 21p11, and 21q11-22. The CGH analysis revealed recurrent gains at 1p, 4q, 17p, and 21q and losses at 3q and 16p. Five amplification sites were observed at 1q11-23, 6p21, 8q13, 8q21.3-24.2, and 17p. The data are discussed and compared with other cytogenetic reports in the literature.