The Epigenomic Landscape in Osteoarthritis.
The Epigenomic Landscape in Osteoarthritis.
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DOI：
10.1007/s11926-017-0661-9
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发表时间：
2017-06
影响因子：
5
通讯作者：
Jeffries MA
中科院分区：
文献类型：
--
作者：
Simon TC;Jeffries MA
表观基因组学已经成为我们对骨关节炎快速发展的理解的关键参与者。历史研究表明表观遗传学改变，特别是DNA甲基化，在OA发病机制;然而，最近的技术进步导致了许多表观基因组范围的研究详细检查OA的表观遗传学修饰。本文的目的是介绍表观遗传学的基本概念及其在骨关节炎发生发展研究中的应用。表观遗传学描述了三种主要现象：通过甲基化进行的DNA修饰、组蛋白侧链修饰和短的非编码RNA序列，这些序列以可遗传的方式协同调节基因转录。软骨是OA中研究最广泛的组织，参与炎症、细胞周期、TGFβ和HOX基因的基因差异甲基化已被多次证实。骨研究表明了类似的发现，以及在许多OA过程中软骨下骨表观遗传变化的有趣可能性。多项研究表明，某些非编码RNA，特别是miR-140，通过调节关键的分解代谢因子参与OA的发展。虽然已经做了很多工作，但仍有很多未知数。未来的表观基因组研究无疑将继续扩大我们对关节外组织和OA发病机制的理解，动物模型的研究可能会提供OA早期阶段表观基因组改变的一瞥。
Epigenomics has emerged as a key player in our rapidly evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations, particularly DNA methylation, in OA pathogenesis; however, recent technological advances have resulted in numerous epigenome-wide studies examining in detail epigenetic modifications in OA. The purpose of this article is to introduce basic concepts in epigenetics and their recent applications to the study of osteoarthritis development and progression. Epigenetics describes three major phenomena: DNA modification via methylation, histone sidechain modifications, and short noncoding RNA sequences which work in concert to regulate gene transcription in a heritable fashion. Cartilage has been the most widely studied tissue in OA, and differential methylation of genes involved in inflammation, cell cycle, TGFβ, and HOX genes have been confirmed several times. Bone studies suggest similar findings, and the intriguing possibility of epigenetic changes in subchondral bone during many OA processes. Multiple studies have demonstrated the involvement of certain noncoding RNAs, particularly miR-140, in OA development via modulation of key catabolic factors. Although much work has been done, much is still unknown. Future epigenomic studies will no doubt continue to widen our understanding of extraarticular tissues and OA pathogenesis, and studies in animal models may offer glimpses into epigenome alterations in the earliest stages of OA.
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影响因子：
2.6
作者：
den Hollander W;Meulenbelt I
通讯作者：
Meulenbelt I
影响因子：
2.3
作者：
Díaz-Prado S;Cicione C;Muiños-López E;Hermida-Gómez T;Oreiro N;Fernández-López C;Blanco FJ
通讯作者：
Blanco FJ
影响因子：
4.8
作者：
Hong, Sohee;Derfoul, Assia;Hall, David J.
通讯作者：
Hall, David J.
影响因子：
--
作者：
Hashimoto, Ko;Oreffo, Richard O. C.;Gibson, Marc B.;Goldring, Mary B.;Roach, Helmtrud I.
通讯作者：
Roach, Helmtrud I.
影响因子：
--
作者：
Akhtar, Nahid;Rasheed, Zafar;Ramamurthy, Sangeetha;Anbazhagan, Arivarasu N.;Voss, Frank R.;Haqqi, Tariq M.
通讯作者：
Haqqi, Tariq M.