Aluminium toxicosis: a review of toxic actions and effects.
Aluminium toxicosis: a review of toxic actions and effects.
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DOI：
10.2478/intox-2019-0007
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发表时间：
2019-10-01
影响因子：
--
通讯作者：
Igbokwe, Nanacha Afifi
中科院分区：
文献类型：
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作者：
Igbokwe, Ikechukwu Onyebuchi;Igwenagu, Ephraim;Igbokwe, Nanacha Afifi
动物和人类经常接触到铝，可能导致中毒。铝的摄入是通过吸入气溶胶或颗粒、摄入食物、水和药物、皮肤接触、接种疫苗、透析和输液。铝的毒性作用可诱导氧化应激、免疫改变、遗传毒性、促炎作用、肽变性或转化、酶功能障碍、代谢紊乱、淀粉样蛋白形成、膜扰动、铁平衡失调、细胞凋亡、坏死和发育不良。与铝中毒相关的病理情况有脱皮性间质性肺炎、肺泡蛋白沉积症、肉芽肿、肉芽肿病和纤维化、中毒性心肌炎、血栓形成和缺血性中风、肉芽肿性肠炎、克罗恩病、炎症性肠病、贫血、阿尔茨海默病、痴呆、硬化症、自闭症、巨噬性肌筋膜炎、骨软化症、少精子症和不孕症、肝肾疾病、乳腺癌和囊肿、胰腺炎、胰腺坏死和糖尿病。该综述提供了铝中毒的广泛概述，作为对公共卫生重要性的铝化合物毒理学持续调查的背景。
Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn's disease, inflammatory bowel diseases, anemia, Alzheimer's disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.