Reorganization between preparatory and movement population responses in motor cortex.
Reorganization between preparatory and movement population responses in motor cortex.
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DOI：
10.1038/ncomms13239
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发表时间：
2016-10-27
影响因子：
16.6
通讯作者：
Cunningham, John P.
中科院分区：
文献类型：
--
作者：
Elsayed, Gamaleldin F.;Lara, Antonio H.;Kaufman, Matthew T.;Churchland, Mark M.;Cunningham, John P.
神经种群可以改变它们在非常短的时间尺度上执行的计算。尽管这种灵活性很常见，但在总体水平上的基本计算策略仍然未知。为了解决这一差距，我们研究了REACH准备和运动过程中运动皮质的群体反应。我们发现存在专用于准备和迁移计算的排他性和正交性的种群级子空间。这种正交性产生了反应相关性的重组：具有共同反应特性的神经元集合在准备和运动之间完全改变。因此，相同的神经群体在不同的时间作为两个独立的电路，具有非常不同的性质。现有的运动皮质模型没有预测到这一发现，这些模型预测了重叠的准备相关和运动相关的子空间。尽管正交性，预备子空间中的反应与移动子空间中的后续反应是合法相关的。这些结果揭示了一种总体水平的策略，用于执行单独但关联的计算。单个神经元的反应是高度复杂和动态的，但它们能够通过集体活动灵活地表示行为。在这里，作者证明了运动皮质神经元的群体活动模式在通过简单的线性函数联系的连续任务时期是正交的。
Neural populations can change the computation they perform on very short timescales. Although such flexibility is common, the underlying computational strategies at the population level remain unknown. To address this gap, we examined population responses in motor cortex during reach preparation and movement. We found that there exist exclusive and orthogonal population-level subspaces dedicated to preparatory and movement computations. This orthogonality yielded a reorganization in response correlations: the set of neurons with shared response properties changed completely between preparation and movement. Thus, the same neural population acts, at different times, as two separate circuits with very different properties. This finding is not predicted by existing motor cortical models, which predict overlapping preparation-related and movement-related subspaces. Despite orthogonality, responses in the preparatory subspace were lawfully related to subsequent responses in the movement subspace. These results reveal a population-level strategy for performing separate but linked computations. Single neuron responses are highly complex and dynamic yet they are able to flexibly represent behaviour through their collective activity. Here the authors demonstrate that population activity patterns of motor cortex neurons are orthogonal during successive task epochs that are linked through a simple linear function.
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