The distribution of cells expressing a natural killer cell marker (HNK-1) in normal human lymphoid organs and malignant lymphomas
The distribution of cells expressing a natural killer cell marker (HNK-1) in normal human lymphoid organs and malignant lymphomas
复制标题
表达自然杀伤细胞标志物（HNK-1）的细胞在正常人淋巴器官和恶性淋巴瘤中的分布
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
T. Shimamine
中科院分区：
文献类型：
--
作者：
S. Mori;N. Mohri;H. Morita;K. Yamaguchi;T. Shimamine
摘要已知鼠单克隆抗体 HNK-1 会与一些人类白细胞发生反应，包括外周血中的所有自然杀伤 (NK) 细胞。研究了与该抗体反应的细胞（HNK-1 + 细胞）在人外周淋巴器官中的分布，该器官由五个淋巴结、两份具有淋巴组织的胃粘膜样本、两个扁桃体、一个阑尾和两个胸腺组成。还检查了十四例恶性淋巴瘤（ML）。为了演示HNK-1 + 细胞，我们将过氧化物酶-抗过氧化物酶（PAP）桥法应用于这些标本的低温切片。结果发现，在正常淋巴器官中，大多数HNK-1 + 细胞位于淋巴滤泡中，特别是生发中心，也有一些发现于“混合”区域，即滤泡和T区外部。ML中，仅在两例病例中观察到大簇的HNK-1 + 细胞。滤泡性淋巴瘤，尽管在其他 ML 中发现了一些分散的 HNK-1 + 细胞，包括 5 例弥漫性 B 细胞淋巴瘤、6 例 T 细胞淋巴瘤和 1 例无效细胞淋巴瘤。讨论了这些发现的可能意义。
SummaryA murine monoclonal antibody, HNK-1, is known to react with some human leukocytes including all natural killer (NK) cells in peripheral blood. The distribution of cells reacting with this antibody (HNK-1 + cell) was studied in human peripheral lymphoid organs, consisting of five lymph nodes, two specimens of gastric mucosa with lymphoid tissue, two tonsils, one appendix, and two thymuses. Fourteen cases of malignant lymphoma (ML) were also examined. For the demonstration of HNK-1 + cells, the peroxidase-antiperoxidase (PAP) bridge method was applied to cryostat sections of these specimens.It was found that in normal lymphoid organs most HNK-1 + cells were located in lymph follicles, especially in germinal centers, and some were found in ‘mixed” regions which indicate outsides of both the follicles and T-zones. Amongst the ML, large clusters of HNK-1 + cells were observed only in two cases of follicular lymphoma, although a few scattered HNK-1 + cells were noted in other ML, including five diffuse B-cell lymphomas, six T-cell lymphomas and one null cell lymphoma. The possible significance of these findings is discussed.
HNK-1 (Leu-7) 人淋巴细胞的表征。
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abo,T;Cooper,MD;Balch,CM
通讯作者：
Balch,CM
通过单克隆抗体 (HNK-1) 识别的人类 NK 和 K 细胞的分化抗原。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abo,T;Balch,CM
通讯作者：
Balch,CM