T cell Receptor Signal Transduction in T lymphocytes.
T cell Receptor Signal Transduction in T lymphocytes.
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DOI：
10.4172/2155-9899.s12-005
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发表时间：
2012-10-27
期刊：
影响因子：
--
通讯作者：
Zhong XP
中科院分区：
文献类型：
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作者：
Gorentla BK;Zhong XP
T细胞受体（TCR）识别由主要组织相容性复合体（MHC）分子呈递的自身或外来抗原。TCR的参与触发多分子信号体的形成，导致第二信使的产生和随后的多个远端信号级联的激活，例如Ca+2-钙调神经磷酸酶-NFAT、RasGRP 1-Ras-Erk 1/2、PKCθ-IKK-NFκB和TSC 1/2-mTOR通路。这些信号级联控制T细胞生物学的许多方面。已经发展了微调TCR信号传导以维持T细胞稳态和自身耐受性的机制，并适当地对微生物感染产生有效反应。TCR信号传导的缺陷或失调已经涉及多种人类疾病的发病机制。
The T cell receptor (TCR) recognizes self or foreign antigens presented by major histocompatibility complex (MHC) molecules. Engagement of the TCR triggers the formation of multi-molecular signalosomes that lead to the generation of second messengers and subsequent activation of multiple distal signaling cascades, such as the Ca+2-calcineurin-NFAT, RasGRP1-Ras-Erk1/2, PKCθ-IKK-NFκB, and TSC1/2-mTOR pathways. These signaling cascades control many aspects of T cell biology. Mechanisms have been evolved to fine-tune TCR signaling to maintain T cell homeostasis and self-tolerance, and to properly mount effective responses to microbial infection. Defects or deregulation of TCR signaling has been implicated in the pathogenesis of multiple human diseases.