Palladium-Catalyzed Highly Diastereoselective Oxidative Cascade Cyclization Reactions
Palladium-Catalyzed Highly Diastereoselective Oxidative Cascade Cyclization Reactions
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DOI：
10.1021/ol900355h
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发表时间：
2009-05-07
期刊：
影响因子：
5.2
通讯作者：
Yang, Dan
中科院分区：
文献类型：
--
作者：
Yip, Kai-Tai;Zhu, Nian-Yong;Yang, Dan
异喹啉和喹啉被发现是钯催化的级联氧化环化反应的新型配体。在我们的新催化剂体系(Pd(OAc)(2)/二氢喹啉或喹啉)下，不饱和苯胺在氧气气氛(1 Atm)下环化，以良好的产率提供结构多样的吲哚衍生物。一步形成一个C-N键和两个C-C键，具有优异的非对映选择性(DR>；24：1)。
Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)(2)/disoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).