Specialized pro-resolving mediators in respiratory diseases.
Specialized pro-resolving mediators in respiratory diseases.
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DOI：
10.1097/mco.0000000000000805
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发表时间：
2022-03-01
影响因子：
3.1
通讯作者：
Levy BD
中科院分区：
文献类型：
--
作者：
Cagnina RE;Duvall MG;Nijmeh J;Levy BD
持续未解决的炎症导致许多病理性呼吸道疾病，包括哮喘、囊性纤维化、急性呼吸窘迫综合征（ARDS）和COVID-19相关的ARDS。炎症消退是由衍生自必需ω-3和ω-6多不饱和脂肪酸（PUFA）的生物活性专门促消退介质（SPM）家族协调的一系列活跃的生物过程。在这篇综述中，我们强调了最近的研究结果失调的炎症决议在常见的呼吸道疾病和最近的文献SPM代与PUFA膳食补充剂与呼吸道炎症疾病。肺部炎症疾病的人体研究和临床前模型已经揭示了促炎介质与促消退介质水平的不平衡。最近的研究确定了SPM在炎症性呼吸道疾病中调节促炎宿主反应和刺激炎症消退途径的作用。膳食海洋油富含PUFA，并含有母体ω-3和ω-6脂肪酸以及转化为SPM的前体。鱼油营养补充剂可以提高SPM水平，并为肺部炎症疾病提供针对炎症解决途径的治疗方法。
Persistent unresolved inflammation results in a number of pathologic respiratory diseases including asthma, cystic fibrosis, acute respiratory distress syndrome (ARDS) and COVID-19-associated ARDS. Inflammation resolution is an active series of biologic processes orchestrated by a family of bioactive specialized pro-resolving mediators (SPMs) derived from essential omega-3 and omega-6 polyunsaturated fatty acids (PUFAs). In this review we highlight recent findings on dysregulated inflammation resolution in common respiratory diseases and recent literature on SPM generation with PUFA dietary supplementation with relevance to diseases of respiratory inflammation. Human studies and pre-clinical models of diseases of lung inflammation have revealed disequilibrium in the levels of pro-inflammatory versus pro-resolving mediators. Recent studies identify actions for SPMs on regulating pro-phlogistic host responses and stimulating inflammation resolution pathways in inflammatory respiratory diseases. Dietary marine oils are enriched in PUFAs and contain parent omega-3 and omega-6 fatty acids and precursors for conversion to SPMs. Nutritional supplementation with fish oils can boost SPM levels and offer a therapeutic approach targeting inflammation resolution pathways for diseases of lung inflammation.