Prognostic significance of melanoma differentiation and trans-differentiation.
Prognostic significance of melanoma differentiation and trans-differentiation.
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DOI：
10.3390/cancers2020989
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发表时间：
2010-06
期刊：
影响因子：
5.2
通讯作者：
Setaluri V
中科院分区：
文献类型：
--
作者：
Maddodi N;Setaluri V
皮肤恶性黑色素瘤具有许多共同的分子属性，如无限的复制潜力，定义了大多数恶性肿瘤获得的能力。因此，许多努力集中在评估和验证与这些能力相关的蛋白质标志物作为黑素瘤预后标志物。然而，一些研究也强调了定义黑素细胞分化的标志物的预后价值和黑色素瘤细胞沿沿着几种其他细胞途径转分化的可塑性。在这里，我们提供了一个全面的审查和评估的黑素细胞谱系标志物，如MITF和黑素蛋白，以及血管上皮和神经元分化的标志物的预后意义。
Cutaneous malignant melanomas share a number of molecular attributes such as limitless replicative potential that define capabilities acquired by most malignancies. Accordingly, much effort has been focused on evaluating and validating protein markers related to these capabilities to function as melanoma prognostic markers. However, a few studies have also highlighted the prognostic value of markers that define melanocytic differentiation and the plasticity of melanoma cells to trans-differentiate along several other cellular pathways. Here, we provide a comprehensive review and evaluation of the prognostic significance of melanocyte-lineage markers such as MITF and melanogenic proteins, as well as markers of vascular epithelial and neuronal differentiation.