The basolateral complex of the amygdala is necessary for acquisition but not expression of CS motivational value in appetitive Pavlovian second-order conditioning
The basolateral complex of the amygdala is necessary for acquisition but not expression of CS motivational value in appetitive Pavlovian second-order conditioning
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DOI：
10.1046/j.1460-9568.2002.02010.x
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发表时间：
2002-06-01
影响因子：
3.4
通讯作者：
Holland, PC
中科院分区：
文献类型：
--
作者：
Setlow, B;Gallagher, M;Holland, PC
杏仁核基底外侧复合体（ABL）参与处理有关刺激动机价值的信息。然而，尚不清楚ABL是否对获取、维护或表达这些信息至关重要。我们以前的工作表明，ABL病变之前的培训，块收购的食欲巴甫洛夫二阶条件反射任务，其中性能被认为是依赖于收购的动机（条件强化）值的一阶条件刺激（CS）。本实验研究的影响ABL病变后，一阶条件反射，当CS获得动机价值，但在二阶条件反射，测试获得价值的CS。大鼠接受配对的视觉CS与食物消化器。然后，他们接受了双边假或兴奋性毒性病变的ABL。恢复后，他们收到配对的二阶听觉CS与以前的条件视觉CS。在两个实验中，假手术和损伤大鼠获得正常的二阶条件行为。然后，一些相同的大鼠被给予另一轮具有新CS的二阶条件反射。在这种情况下，当手术后进行一阶训练时，损伤大鼠的一些二阶条件行为受损。二阶条件行为的关联基础的测试表明，ABL病变受损的行为是基于刺激反应协会。结果表明，虽然ABL是关键的二阶条件反射，这种作用是有限的收购信息的动机价值的一阶CS，它不是关键的维护这些信息或使用它在形成二阶协会。
The basolateral complex of the amygdala (ABL) is involved in processing information about stimulus motivational value. However, it is not clear whether the ABL is critical for acquisition, maintenance, or expression of this information. Our previous work has shown that ABL lesions made prior to training, block acquisition of an appetitive Pavlovian second-order conditioning task, in which performance is thought to depend on the acquisition of motivational (conditioned reinforcement) value by the first-order conditioned stimulus (CS). The present experiments examined the effects of ABL lesions made after first-order conditioning, when the CS acquires motivational value, but before second-order conditioning, the test for acquired value of that CS. Rats received pairings of a visual CS with a food reinforcer. They then received bilateral sham or excitotoxic lesions of the ABL. After recovery, they received pairings of a second-order auditory CS with the previously conditioned visual CS. In two experiments, both sham and lesioned rats acquired normal second-order conditioned behaviours. Some of the same rats were then given another round of second-order conditioning with novel CSs. In this case, when first-order training occurred after surgery, some second-order conditioned behaviours were impaired in lesioned rats. Tests of the associative underpinnings of second-order conditioned behaviours showed that those behaviours impaired by ABL lesions were based on stimulus-response associations. The results show that although the ABL is critical for second-order conditioning, this role is limited to acquisition of information about the motivational value of the first-order CS, and it is not critical for maintenance of this information or for its use in forming second-order associations.