IDENTIFICATION OF A HUMAN NEUROECTODERMAL TUMOR-ANTIGEN (OFA-I-2) AS GANGLIOSIDE GD2
IDENTIFICATION OF A HUMAN NEUROECTODERMAL TUMOR-ANTIGEN (OFA-I-2) AS GANGLIOSIDE GD2
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DOI：
10.1073/pnas.79.24.7629
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
PAULSON, JC
中科院分区：
文献类型：
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作者：
CAHAN, LD;IRIE, RF;PAULSON, JC
由源自黑素瘤患者的淋巴母细胞系在体外产生的两种单特异性人抗体（抗OFA-I-1和抗OFA-I-2）先前已显示识别人肿瘤和胎儿脑上的细胞表面抗原（OFA-I-1和OFA-I-2）：OFA-I-1在多种人肿瘤上表达，而OFA-I-2仅在神经外胚层来源的肿瘤上检测到。本报告提供的证据表明，由培养的人黑素瘤细胞系（M14）表达的2种抗原在化学上是不同的，OFA-I-2是细胞表面糖脂，神经节苷脂GD 2：**图形 **。
Two monospecific human antibodies (anti-OFA-I-1 and anti-OFA-I-2) produced in vitro by lymphoblast cell lines originating from melanoma patients have been shown previously to recognize cell surface antigens (OFA-I-1 and OFA-I-2) on human tumors and fetal brain: OFA-I-1 is expressed on a variety of human tumors, while OFA-I-2 has been detected only on tumors of neuroectodermal origin. Evidence presented in this report suggests that the 2 antigens expressed by a cultured human melanoma cell line (M14) are chemically distinct and that OFA-I-2 is a cell surface glycolipid, ganglioside GD2: .**GRAPHIC**.