Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well
Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well
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DOI：
10.1080/08860220600779033
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发表时间：
2006-01-01
期刊：
影响因子：
3
通讯作者：
Savci, Vahide
中科院分区：
文献类型：
--
作者：
Gullulu, Mustafa;Akdag, Ibrahim;Savci, Vahide
最近的研究表明，醛固酮不仅在电解质和水分平衡和钾的排泄中起着重要作用，而且它还调节心脏和血管中的肌成纤维细胞的生长并导致纤维化。这项研究通过与血管紧张素受体抑制剂valsartan的比较，研究了醛固酮阻滞剂对抗Thy 1.1肾炎大鼠的增殖和纤维化的影响。将抗Thy 1.1肾炎大鼠随机分为3组：对照组(第1组)、醛固酮受体阻滞剂螺内酯(第2组)和ATRB valsartan(第3组)。第7天测定肾小球纤维化指标[转化生长因子β、转化生长因子染色面积%]、增殖指数(Ki-67)和肾损害评分。对照组TGF-β和Ki-67水平显著高于其他两组(p<；0.01)。TGF染色面积百分比较对照组明显减少。两组之间评估的动脉、肾小球和肾脏损伤评分与对照组相比显著降低。与以前的研究一致，这项研究发现在抗Thy 1.1系膜增生性肾小球肾炎中，醛固酮阻断影响增殖和纤维化。
Studies performed recently have determined that aldosterone has not only a major role in electrolyte and water balance and K excretion, but it also modulates myofibroblast growth in the heart and blood vessels and causes fibrosis. This study investigated the effects of aldosterone blockers in rats with anti-thy 1.1 nephritis, both on proliferation and fibrosis, by comparing it to an angiotensin receptor inhibitor valsartan. Rats with anti-thy 1.1 nephritis were randomly allocated to one of the three following groups of treatment: the control group ( group 1); those treated with the aldosterone receptor blocker spironolactone ( group 2); and those treated with the ATRB valsartan ( group 3). On day 7, the parameters of glomerular fibrosis [ transforming growth factor beta, TGF staining areas %], proliferation (Ki-67), and renal damage scores were determined. The TGF-beta and Ki-67 levels of control group were significantly more than the other two groups (p < 0.01). The TGF staining areas percentages were significantly decreased compared to control group. The artery, glomerular, and renal injury scores evaluated between the groups were found to be significantly decreased compared to control group. In line with previous studies, this study found that in anti-thy 1.1 mesangioproliferative glomerulonephritis, aldosterone blockage affected proliferation and fibrosis.