Matrix Metalloproteinases (MMP-2 and MMP-9) and Cyclooxygenase-2 (COX-2) Expressions in Vocal Fold Polyps
Matrix Metalloproteinases (MMP-2 and MMP-9) and Cyclooxygenase-2 (COX-2) Expressions in Vocal Fold Polyps
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DOI：
10.1016/j.jvoice.2007.05.005
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发表时间：
2009-01-01
期刊：
影响因子：
2.2
通讯作者：
Kapucuoglu, Nilgun
中科院分区：
文献类型：
--
作者：
Karahan, Nermin;Baspinar, Sirin;Kapucuoglu, Nilgun
本研究旨在探讨基质金属蛋白酶（MMP-2、MMP-9）和环氧合酶（考克斯-2）在声带息肉（VFP）发病中的作用。在这项研究中，20个VFP和8个正常声带（VF）标本来自接受手术的受试者。染色强度进行半定量评估和统计学分析。MMP-2、MMP-9的表达明显增加。考克斯-2在VFPs间质梭形细胞（P = 0.00）和血管壁（P = 0.04，P = 0.00，P = 0.00）中的表达明显高于正常VFPs。MMP-2在VFPs表面上皮基底细胞的表达较正常声带明显增强（P = 0.00）。而MMP-9和考克斯-2的表达无显著性差异。我们的研究表明明胶酶和考克斯-2可能在VFP的发生发展中起作用。这是首次研究明胶酶和考克斯-2在VFP中的表达。
The objective Of this Study was to investigate the roles of matrix metalloproteinases (MMP-2, MMP-9) and cyclooxygenase-2 (COX-2) in the pathogenesis of vocal fold polyps (VFPs). Ill this study, 20 VFPs and 8 normal vocal fold (VF) specimens were obtained from subjects undergoing surgery. Staining intensities were semiquantitatively assessed and statistically analyzed. Significant increases were observed ill the expressions of MMP-2, MMP-9. and COX-2 ill stromal spindle cells (P = 0.00) and vascular wall (P = 0.04, P = 0.00, P = 0.00) of VFPs compared with normal VFs. MMP-2 expression ill surface epithelium basal cells (P = 0.00) of VFPs showed enhancement compared with normal vocal folds. whereas MMP-9 and COX-2 expressions showed no significant differences. Our study showed that gelatinases and COX-2 may play a role in the development of VFPs, This is the first Study to document the expression Of gelatinases and COX-2 in VFPs.