Risk factors for leukemia occurrence among growth hormone users.
Risk factors for leukemia occurrence among growth hormone users.
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DOI：
10.1111/j.1349-7006.1989.tb01721.x
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发表时间：
1989-09
期刊：
影响因子：
--
通讯作者：
Komiyama A
中科院分区：
文献类型：
--
作者：
Watanabe S;Yamaguchi N;Tsunematsu Y;Komiyama A
在生长激素（GH）使用者中进行了一项关于白血病发生率的匹配病例对照研究，以阐明白血病的任何风险因素。GH的总剂量和其他激素，如甲状腺素，促性腺激素，性腺激素，糖皮质激素和合成代谢类固醇的管理，并没有导致任何明显的差异研究病例和对照组之间。诊断性X射线和治疗性颅脑照射的剂量与白血病风险无关。使用放射性碘进行甲状腺功能闪烁照相术是唯一显著的危险因素（P=0.03）。比较了GH治疗前和治疗后1个月的血液学和肝功能变化，结果显示白色细胞增殖反应较强，中性粒细胞迅速增加，而淋巴细胞反应则不稳定。乳酸脱氢酶、碱性磷酸酶、谷氨酸-乙酸转氨酶、谷氨酸-丙氨酸转氨酶在GH治疗后有降低的趋势。其他环境和家族因素未显示任何异常聚集。
A matched case‐control study on leukemia occurrence among growth hormone (GH) users was performed to elucidate any risk factor for leukemia. The total doses of GH and administration of other hormones, such as thyroxine, gonadotropin, gonadal hormones, glucocorticoid and anabolic steroid, did not lead to any apparent difference between cases studied and controls. Neither doses of diagnostic X‐rays nor therapeutic cranial irradiation was related to leukemia risk. Scintigraphy for thyroid function using radioactive iodide was the only significant risk factor (P=0.03). Hematological changes and liver function before and one month after GH administration were compared and the cases studied showed more proliferative reaction of white blood cells with rapid increase of neutrophils, but lymphocyte response was variable. Lactic acid dehydrogenase, alkaline phosphatase, glutamic oxalacetic transaminase, glutamic pyruvic transaminase tended to decrease after GH treatment when the patients had shown abnormally increased levels. Other environmental and familial factors did not show any abnormal clusters.