Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge.
Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge.
复制标题
DOI：
10.4252/wjsc.v6.i3.266
复制
发表时间：
2014-07-26
影响因子：
4.1
通讯作者：
Mattioli-Belmonte, Monica
中科院分区：
文献类型：
--
作者：
Ferretti, Concetta;Mattioli-Belmonte, Monica
骨膜是覆盖大多数骨骼的薄纤维层。它存在于动态的机械负载环境中，为多能细胞提供了生态位，并为调节细胞行为的分子因子提供了来源。骨膜再生潜能的研究已成为骨科研究的热点。本文综述了基于骨膜来源祖细胞的骨软骨组织工程的研究现状，并提出了今后的研究方向。骨膜细胞的分离，鉴定和迁移在损伤部位，以及它们的分化，进行了分析。此外，细胞力学传感的作用及其对基质组织，骨微结构和骨强度的贡献进行了检查。在这方面，考虑了骨膜蛋白的作用及其在机械应力下的上调以保持PDPC存活和骨组织完整性。本文还对骨膜在口腔颌面部重建中的作用进行了综述。microRNA参与成骨细胞分化和内源性组织修复也进行了探讨。最后，基于骨膜本身作为智能材料的使用和能够模仿细胞外基质特征的构建体的实现，讨论了引导骨再生的新概念。此外，由于骨膜可以分化为胰岛素产生细胞，因此它可能是同种异体移植的合适来源。创新应用将从旨在评估PDPC免疫豁免的研究中获益。
Periosteum is a thin fibrous layer that covers most bones. It resides in a dynamic mechanically loaded environment and provides a niche for pluripotent cells and a source for molecular factors that modulate cell behaviour. Elucidating periosteum regenerative potential has become a hot topic in orthopaedics. This review discusses the state of the art of osteochondral tissue engineering rested on periosteum derived progenitor cells (PDPCs) and suggests upcoming research directions. Periosteal cells isolation, characterization and migration in the site of injury, as well as their differentiation, are analysed. Moreover, the role of cell mechanosensing and its contribution to matrix organization, bone microarchitecture and bone stenght is examined. In this regard the role of periostin and its upregulation under mechanical stress in order to preserve PDPC survival and bone tissue integrity is contemplated. The review also summarized the role of the periosteum in the field of dentistry and maxillofacial reconstruction. The involvement of microRNAs in osteoblast differentiation and in endogenous tissue repair is explored as well. Finally the novel concept of a guided bone regeneration based on the use of periosteum itself as a smart material and the realization of constructs able to mimic the extracellular matrix features is talked out. Additionally, since periosteum can differentiate into insulin producing cells it could be a suitable source in allogenic transplantations. That innovative applications would take advantage from investigations aimed to assess PDPC immune privilege.