EFFECTS OF BORDETELLA-BRONCHISEPTICA DERMONECROTIZING TOXIN ON BONE-FORMATION IN CALVARIA OF NEONATAL RATS
EFFECTS OF BORDETELLA-BRONCHISEPTICA DERMONECROTIZING TOXIN ON BONE-FORMATION IN CALVARIA OF NEONATAL RATS
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DOI：
10.1111/j.1574-695x.1995.tb00170.x
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发表时间：
1995-09-01
影响因子：
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通讯作者：
MATSUDA, M
中科院分区：
文献类型：
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作者：
HORIGUCHI, Y;OKADA, T;MATSUDA, M
采用纯化毒素制剂，研究了支气管霉菌皮腐毒素对骨形成的影响。将毒素4.3 ng单次注射到新生大鼠坏死顶骨骨膜和退化成骨细胞的颅骨上覆皮下组织2天内。注射后第9天，骨组织病变严重；骨基质变得薄而破碎。这些观察结果表明，没有其他因素的微生物产生的皮肤腐蚀毒素损害骨的形成。
The effects of Bordetella bronchiseptica dermonecrotizing toxin on bone formation were investigated using a purified toxin preparation. Single injection of 4.3 ng of the toxin into the subcutaneous tissue overlying the calvariae of neonatal rats necrotized periosteum of parietal bone and degenerated osteoblasts within two days. Nine days after the injection, the lesion of the bone tissue became severe; the bone matrix became thin and fragmented. These observations indicate that dermonecrotizing toxin without other factors produced by the organisms impairs bone formation.