Toxicology screening in acute spinal cord injury.
Toxicology screening in acute spinal cord injury.
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急性脊髓损伤的毒理学筛查。
DOI：
10.1111/j.1530-0277.1988.tb01352.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Keen,M
中科院分区：
文献类型：
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作者：
Heinemann,AW;Schnoll,S;Brandt,M;Maltz,R;Keen,M
通过比较自我报告与血清和尿液分析，对88例急性脊髓损伤（SCI）患者入院时自我报告中毒的有效性进行了检查。血清乙醇大于50 mg/dl是最常见的物质（在40%的病例中观察到），其次是可卡因（14%）、大麻素（8%）、苯二氮卓类药物（5%）和阿片类药物（4%）的尿液分析证据。在35%的样本中，在尿液中发现了可能滥用的物质。虽然62%的样本的血清乙醇大于50 mg/dl或尿液分析阳性，但只有42%的样本报告在SCI时受到某种物质的影响。尽管这两项指标之间的关系具有统计学意义，但在34%的病例中，自我报告和毒理学分析不一致。这些结果表明，如果仅将物质的存在解释为中毒的证据，则SCI中心入院时的常规药物检测将产生假阴性和假阳性结果。
The validity of self‐reported intoxication at time of spinal cord injury (SCI) was examined for 88 cases at admission to an acute SCI center by comparing self‐reports with serum and urine analyses. Serum ethanol greater than 50 mg/dl was the most frequently found substance (observed in 40% of the cases) followed by urine analysis evidence of cocaine (14%), cannabinoids (8%), benzodiazipines (5%), and opiates (4%). Evidence of substances with abuse potential was found in urine for 35% of the sample. While 62% of the sample had either serum ethanol greater than 50 mg/dl or a positive urine analysis, only 42% of the sample reported being under the influence of some substance at the time of SCI. Although the relationship between these two measures was statistically significant, self‐report and toxicology analyses were discordant in 34% of the cases. These results suggest that routine drug testing at admission to an SCI center will produce both false‐negative and false‐positive results if substance presence alone is interpreted as evidence of intoxication.