Predictors of Survival in HIV-Infected Patient after Initiation of HAART in Zewditu Memorial Hospital, Addis Ababa, Ethiopia.
Predictors of Survival in HIV-Infected Patient after Initiation of HAART in Zewditu Memorial Hospital, Addis Ababa, Ethiopia.
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DOI：
10.1155/2014/250913
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Kumie, Abera
中科院分区：
文献类型：
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作者：
Mengesha, Shibre;Belayihun, Bekele;Kumie, Abera
介绍。抗逆转录病毒治疗提高了艾滋病毒感染者的生存率。然而，资源贫乏国家的患者死亡率较高，特别是在开始抗逆转录病毒治疗后的头几个月。在这项研究中，我们试图确定在Zewditu纪念医院接受HAART治疗的hiv感染患者的生存因素。方法。回顾性队列研究于2008年至2012年进行。所有14岁以上的艾滋病毒感染者都接受了一线抗逆转录病毒治疗。使用Epi Info 7和SPSS Version 20收集、输入和分析数据。生命表用于估计ART开始后的死亡率，Kaplan-Meier法用于比较生存曲线。采用Cox比例风险模型评估死亡率预测因子。结果。死亡率为3.8/100人年。死亡率的独立预测因子是WHO临床阶段3-4 （HR = 2.39, 95% CI(1.26, 5.31)）、贫血（血红蛋白水平< 10gm/dL） （HR = 5.54, 95% CI(2.58, 11.86)）。结论。发现死亡率相对较低，大多数死亡发生在开始抗逆转录病毒治疗的3个月内。世卫组织3-4期、贫血（血红蛋白计数< 10gm/dL）和既往结核合并感染是死亡率的主要预测因素。应调查晚期患者早期死亡的潜在原因。
Introduction. ART has improved the survival of HIV-infected patients. However, patients in resource-poor countries have higher mortality rates, particularly the first months after initiating ART. In this study we tried to determine the survival factors in HIV-infected patients treated with HAART in Zewditu Memorial Hospital. Methods. A retrospective cohort study was conducted from 2008 to 2012. All HIV-infected patients above the age of 14 took first line ART. Data were collected, entered, and analyzed using Epi Info 7 and SPSS Version 20. Life table was used to estimate mortality after initiation of ART, and Kaplan-Meier was used to compare survival curves. Cox proportional hazards model was used to assess the predictors of mortality. Results. The incidence of mortality was 3.8/100 person-years. Independent predictors of mortality were WHO clinical stages 3-4 (HR = 2.39 at 95% CI (1.26, 5.31)), anemia (hemoglobin level < 10gm/dL (HR = 5.54 at 95% CI (2.58, 11.86)). Conclusion. Incidence of mortality was found relatively low, majority of deaths occurring within 3 months of starting ART. WHO stages 3-4, anemia (hemoglobin count < 10gm/dL), and past TB coinfection were the main predictors of mortality. The underlying causes for early death in patients presenting at late stages should be investigated.