Erythrocyte transport efficacy of human blood: a rheological point of view
Erythrocyte transport efficacy of human blood: a rheological point of view
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DOI：
10.1111/j.1365-2362.2005.01562.x
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发表时间：
2005-11-01
影响因子：
5.5
通讯作者：
Toth, K
中科院分区：
文献类型：
--
作者：
Bogar, L;Juricskay, I;Toth, K
背景大规模流行病学研究表明，贫血和多细胞血症都是独立的心血管危险因素。弗雷明汉研究证实了这一点，该研究表明血红蛋白浓度与死亡率之间存在 U 形关系。先前指出，以血细胞比容的函数描绘相应的血细胞比容/血液粘度比提供了倒U形曲线的分布。该峰值具有重要的生理意义，因为它表示相对较高的氧结合能力和适度较低的血液粘度之间的健康平衡。本研究的目的是检验血细胞比容和血细胞比容/血液粘度比之间的数学关系。 材料和方法在一项回顾性研究中，分析了 32 名健康对照者、52 名高脂血症门诊患者和 120 名雷诺氏病门诊患者的血液流变学数据。使用 Hevimet 40 毛细管粘度计在 37.0°C、剪切速率 10 s(-1)、90 s(-1) 和 200 s(-1) 下测量全血粘度。 结果 健康受试者、高脂血症和雷诺氏病门诊患者组中，红细胞比容/血液粘度比值与血细胞比容值的函数呈高斯相关。峰值（即流变学最佳红细胞比容）与剪切率和组相关，在 90 s(-1) 剪切率下，对照组、高脂血症患者和雷诺氏病患者的峰值分别为 44.3%、43.5% 和 38.3%。 结论 这是使用红细胞比容/血液粘度确定理论上最佳红细胞比容值的首批报告之一比率。需要进一步的研究来检验这种方法的潜在临床用途。
Background Large-scale epidemiological studies have demonstrated that both anaemia and polycytaemia are independent cardiovascular risk factors. This was substantiated by the Framingham study, which demonstrated a U-shaped relation between haemoglobin concentration and mortality. It was previously noted that delineating the corresponding haematocrit/blood viscosity ratios in the function of haematocrit provided a distribution of an inverted U-shaped curve. The peak appeared physiologically important because it denotes a healthy balance between a relatively high oxygen binding capacity and a moderately low blood viscosity. It was the aim of this study to examine the mathematical relationship between the haematocrit and haematocrit/blood viscosity ratio.Materials and methods In a retrospective study, the haemorheological data of 32 healthy controls, 52 outpatients with hyperlipidaemia and 120 outpatients with Raynaud's disease were analyzed. Whole blood viscosity was measured with Hevimet 40 capillary viscometer at 37.0 degrees C and at shear rates of 10 s(-1), 90 s(-1) and 200 s(-1).Results Haematocrit/blood viscosity ratios in the function of haematocrit values showed a Gaussian association in the healthy subjects, hyperlipidaemic and Raynaud's disease outpatient groups. Peak values (i.e. the rheologically optimal haematocrit) were shear-rate and group dependent and were found at 44.3%, 43.5% and 38.3% in controls, hyperlipidaemic and Raynaud's disease patients, respectively, at a shear rate of 90 s(-1).Conclusions This is one of the first reports in which a theoretically optimal haematocrit value was determined using the haematocrit/blood viscosity ratio. Further studies are needed to examine the potential clinical usefulness of this approach.