Expressions of Orphan Nuclear Receptor TR3/Nur77 in Chronic Hepatopathy and Its Clinical Significance.
Expressions of Orphan Nuclear Receptor TR3/Nur77 in Chronic Hepatopathy and Its Clinical Significance.
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DOI：
10.4172/2324-9110.1000188
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Yingling Zeng;X. Ye;D. Liao;Shizhang Huang;Huinan Mao;Dezheng Zhao;H. Zeng
中科院分区：
文献类型：
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作者：
Yingling Zeng;X. Ye;D. Liao;Shizhang Huang;Huinan Mao;Dezheng Zhao;H. Zeng
目的虽然肿瘤治疗取得了很大的成功，但目前的肿瘤治疗方法，包括抗肿瘤和抗血管生成，除了毒副作用外，还面临着疗效不足、耐药性和内在顽固性等问题。人们需要确定更多可以被阻止的靶点，以关闭大多数(如果不是全部)途径的下游影响。我们的研究表明，孤儿核受体TR3(人)/Nur77(小鼠)就是这样一个靶点。最近，我们报道了TR3/Nur77在人肝癌组织中的表达与肿瘤进展密切相关，提示TR3是肝癌的特异性治疗靶点。然而，TR3/Nur77在肝细胞癌中的表达与慢性肝炎的相关性尚未见报道。方法采用免疫组织化学方法检测有完整病史的人原发性肝癌组织中TR3/Nur77的表达。统计分析癌旁组织、肝硬变组织和慢性肝炎组织中TR3表达的意义。结果TR3/Nur77在肝细胞癌、癌性肝硬变和慢性肝炎中的阳性表达率分别为66.67%、30%和20%，差异有统计学意义(P<；0.05)。在肝细胞癌中，TR3/Nur77的阳性表达率分别为81.25%和20%，差异有统计学意义(P<0.05)。结论TR3/Nur77在肝细胞癌中的阳性表达率高于慢性肝炎和肝硬变。在有乙肝病毒感染的肝细胞癌中，TR3/Nur77的表达阳性率明显高于未感染的肝细胞癌。结果提示，TR3/Nur77在慢性肝炎的发生、发展及肝细胞癌的发生发展中起重要作用。
OBJECTIVE Although great success has been achieved in cancer treatment, current cancer therapies, including anti-tumorigenesis and anti-angiogenesis, still face the problems of insufficient efficacy, resistance and intrinsic refractoriness, in addition to their toxic side effects. There is a demand to identify additional targets that can be blocked to turn off the downstream effects of most, if not all, pathways. Our studies suggest that orphan nuclear receptor TR3 (human)/Nur77 (mouse) is such a target. Most recently, we reported that TR3/Nur77 expression in human hepatic cancer tissues correlates well with tumor progress, suggesting that TR3 is a specific therapeutic target for hepatic cancers. However, the correlation of TR3/Nur77 expression in hepatocellular carcinoma (HCC) with chronic hepatitis has not been studied. METHODS The expression of TR3/Nur77 was analyzed in human primary hepatic cancer specimens from patients that have complete medical records with Immunohistochemically staining. The statistical analysis was used to access the significance of TR3 expression in tumor tissues, cirrhosis tissues and chronic hepatitis tissues with and without hepatitis B virus infection (HBV(+) and HBV(-)), which were obtained from para-tumor tissues. RESULTS The positive rates of TR3/Nur77 expression in hepatocellular carcinoma, cancerous liver cirrhosis and chronic hepatitis are 66.67%, 30%, and 20%, respectively, which are statistic significant (p<0.05). The positive rates of TR3/Nur77 expression in hepatocellular carcinoma are statistic significant (p<0.05) with 81.25% and 20% in HBV (+) or HBV (-), respectively. CONCLUSION The positive expression rate of TR3/Nur77 in hepatocellular carcinoma is higher than that in chronic hepatitis and cirrhosis. The positive rate of TR3/Nur77 expression in hepatocellular carcinoma is higher with HBV infection than that without infection. Our results suggest that TR3/Nur77 plays an important role in the progression of chronic hepatitis, and the occurrence and development of HCC.