Dose and time dependencies of 5‐fluorouracil pharmacokinetics

Dose and time dependencies of 5‐fluorouracil pharmacokinetics
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5-氟尿嘧啶药代动力学的剂量和时间依赖性

DOI:
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发表时间:
2000
期刊:
Clinical pharmacology and therapy
影响因子:
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通讯作者:
E. Chatelut
E. Chatelut
中科院分区:
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文献类型:
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作者:
C. Terret;Eric Erdociain;R. Guimbaud;M. Boisdron;H. McLeod;Régine Féty‐Deporte;T. Lafont;E. Gamelin;R. Bugat;P. Canal;E. Chatelut

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本研究的目的是检查5-氟尿嘧啶的Michaelis-Menten血浆参数的患者间和患者内变异性,5-氟尿嘧啶按照联合推注400 mg/m2,随后连续2天输注600 mg/m2 22小时的方案给药。患者:采用药代动力学群体方法分析21例结直肠癌患者的数据。
The purpose of this study was to examine the interpatient and intrapatient variability of the Michaelis‐Menten plasma parameters of 5‐fluorouracil administered according to a schedule combining a bolus of 400 mg/m2 followed by 22‐hour infusion of 600 mg/m2 for 2 consecutive days. Patients: A pharmacokinetic population approach was used to analyze the data from 21 patients with colorectal cancer.
DOI: 10.1177/0091270010376966
发表时间: 2010-09-01
影响因子: 2.9
作者:
Krzyzanski, Wojciech;Wiczling, Pawel;Balser, Sigrid
通讯作者: Balser, Sigrid