ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions.

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways. The fidelity of intracellular vesicular trafficking depends on proper activations and precise subcellular distributions of ARF family proteins regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Here we review recent progress in understanding the membrane recruitment, activation, crosstalk, and functions of ARF family proteins.

ADP - 核糖基化因子（ARF）家族的鸟嘌呤核苷酸结合蛋白成员在各种细胞过程中发挥关键作用，尤其在调节分泌和内吞途径方面。细胞内囊泡运输的准确性取决于受鸟嘌呤核苷酸交换因子（GEFs）和GTP酶激活蛋白（GAPs）调节的ARF家族蛋白的适当激活和精确的亚细胞分布。在此，我们综述了在理解ARF家族蛋白的膜募集、激活、串扰和功能方面的最新进展。