Regional mu opioid receptor regulation of sensory and affective dimensions of pain
Regional mu opioid receptor regulation of sensory and affective dimensions of pain
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DOI：
10.1126/science.1060952
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发表时间：
2001-07-13
期刊：
影响因子：
56.9
通讯作者：
Stohler, CS
中科院分区：
文献类型：
--
作者：
Zubieta, JK;Smith, YR;Stohler, CS
内源性阿片系统参与应激反应、疼痛体验的调节以及止痛阿片类药物的作用。我们研究了持续疼痛的健康受试者大脑中阿片系统和Mu-阿片受体的功能。持续的疼痛导致内源性阿片类药物的局部释放，这些内源性阿片类药物与Mu-阿片受体在大脑皮层和皮质下的一些区域相互作用。Mu-阿片受体系统的激活与疼痛体验的感觉和情感评分的降低有关，并伴有明显的神经解剖学损害。这些数据证明了Mu-阿片受体及其内源性配体在调节疼痛体验的感觉和情感成分中的中心作用。
The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid system and mu -opioid receptors in the brains of healthy human subjects undergoing sustained pain. Sustained pain induced the regional release of endogenous opioids interacting with mu -opioid receptors in a number of cortical and subcortical brain regions. The activation of the mu -opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. These data demonstrate the central role of the mu -opioid receptors and their endogenous Ligands in the regulation of sensory and affective components of the pain experience.