THE FOS COMPLEX AND FOS-RELATED ANTIGENS RECOGNIZE SEQUENCE ELEMENTS THAT CONTAIN AP-1 BINDING-SITES
THE FOS COMPLEX AND FOS-RELATED ANTIGENS RECOGNIZE SEQUENCE ELEMENTS THAT CONTAIN AP-1 BINDING-SITES
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DOI：
10.1126/science.2964084
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发表时间：
1988-03-04
期刊：
影响因子：
56.9
通讯作者：
CURRAN, T
中科院分区：
文献类型：
--
作者：
FRANZA, BR;RAUSCHER, FJ;CURRAN, T
Fos蛋白复合物和几种Fos相关抗原直接或间接结合到一个共同的序列元件上，该元件与HeLa细胞激活蛋白1 （AP-1）的一致结合位点相似。该元件存在于分化敏感脂肪细胞基因aP2的负调控序列中；长臂猿白血病病毒的转录增强子；在人类免疫缺陷病毒（HIV）长末端重复序列的一个区域中，部分特征为负调控元件。钙离子载体处理CD4+人淋巴母细胞H9后，Fos和Fos相关抗原的蛋白水平和结合活性迅速增加。这些数据表明，一些蛋白质可能与AP-1结合位点相关。此外，对每种蛋白质水平的暂时调节控制可能代表了这些假定的基因表达介质的调节机制。
The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4+ human lymphoblast cell line, H9. These data suggest that several proteins may associated with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.