Red cell cotransport activity and sodium content in black men. Relationship to essential hypertension.
Red cell cotransport activity and sodium content in black men. Relationship to essential hypertension.
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黑人的红细胞协同转运活性和钠含量。
DOI：
10.1161/01.hyp.6.5.724
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Berman,MA
中科院分区：
文献类型：
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作者：
Ringel,RE;Hamlyn,JM;Schaeffer,J;Hamilton,BP;Kowarski,AA;Blaustein,MP;Berman,MA
测定了90名患有和不患有原发性高血压（EH）的成年黑人男性红细胞（红细胞，RBC）中呋塞米敏感性钠和钾共转运和细胞内钠含量（[Na]i）。钠共转运活性的平均值，表示为呋塞米敏感性钠流出（mmol/L RBC/hr），在EH患者和两个对照组之间没有显著差异，两个对照组是具有阳性高血压病史（N+）和具有阴性高血压病家族史（N-）的正常血压受试者（EH：154 +/- 123，n = 53; N+：167 +/- 93，n = 12;和N-：207 +/- 142，n = 20;所有值均为平均值+/- SD）。EH组的平均[Na]i 9.66 +/- 3.02 mmol/L RBC（n = 56）大于N-对照组的平均值（7.96 +/- 1.97，n = 20; p小于0.05）。N+组的平均[Na]i也较高（10.38 +/- 3.18，n = 12; N+ vs N- p <0.01）。虽然组间[Na]i值存在大量重叠，且无明显分界线，但EH组[Na]i值的分布曲线比N-组偏向更高的浓度。尽管如此，我们必须得出结论，红细胞共转运和[Na]i是没有临床上有用的识别高血压在黑人男性。
Furosemide-sensitive sodium and potassium cotransport and intracellular sodium content ([Na]i) were measured in erythrocytes (red blood cells, RBCs) from a population of 90 adult black men with and without essential hypertension (EH). The mean values for sodium cotransport activity, expressed as furosemide-sensitive Na efflux (mmol/liter RBC/hr), were not significantly different among the EH patients and two control groups, normotensive subjects with a positive history (N+) and those with a negative family history (N-) for hypertensive disease (EH: 154 +/- 123, n = 53; N+: 167 +/- 93, n = 12; and N-: 207 +/- 142, n = 20; all values are means +/- SD). The mean [Na]i 9.66 +/- 3.02 mmol/liter RBC (n = 56) for the EH group was greater than the mean value for the N- control group (7.96 +/- 1.97, n = 20; p less than 0.05). The N+ group also displayed a higher mean [Na]i (10.38 +/- 3.18, n = 12; N+ vs N- p less than 0.01). Although there was substantial overlapping of [Na]i values between the groups and no clear dividing line, the distribution curve of the [Na]i values in EH was skewed toward higher concentrations than in N-. Nevertheless, we must conclude that erythrocyte cotransport and [Na]i are not clinically useful in the identification of EH in black men.