Salt intake and renal hemodynamics in immature and mature Dahl salt-sensitive (DS/JR) and salt-resistant (DR/JR) rats.
Salt intake and renal hemodynamics in immature and mature Dahl salt-sensitive (DS/JR) and salt-resistant (DR/JR) rats.
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DOI：
10.1093/ajh/3.4.268
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发表时间：
1990-04
影响因子：
3.2
通讯作者：
J. Hua;F. Kaskel;C. Juno;L. Moore;J. Mccaughran
中科院分区：
文献类型：
--
作者：
J. Hua;F. Kaskel;C. Juno;L. Moore;J. Mccaughran
为了确定Dahl盐敏感大鼠肾功能成熟异常是否与高血压的发生有关，对麻醉的3周龄盐敏感(DS/JR)和耐盐(DR/JR)大鼠进行了研究，这些大鼠的母亲在孕期和产后分别摄入0.15%(低盐)和0.15%或2.0%(高盐)NaCl日粮。成熟的DS/JR和DR/JR大鼠在断奶后分别饲喂0.15%和2.0%NaCl2饲料，在8~9周龄时进行研究。高盐饮食使成年DS/JR大鼠血压升高，肾小球滤过率(GFR)和肾血流量(RBF)降低，而对成熟DR/JR大鼠的BP、GFR和RBF无影响。在未成熟的DS/JR和DR/JR动物中，高盐摄入导致生长不良，DS/JR组的GFR和RBF减少。不同组间对急性扩容(5%体重生理盐水输注)的反应不同。成熟大鼠血管扩张，未成熟高盐DS/JR组无，未成熟低盐DS/JR组血管收缩。这些研究表明，成熟和未成熟的DS/JR大鼠都表现出对急性和慢性盐负荷的异常反应。DS/JR组早期高盐摄入影响肾功能成熟。在DS/JR大鼠出生后发育的关键时期，血管对钠的敏感性增强。
To determine if abnormalities in the maturation of renal function in Dahl salt-sensitive rats are associated with the development of hypertension, studies were performed in anesthetized 3 week old salt-sensitive (DS/JR) and salt-resistant (DR/JR) rats whose mothers were maintained on 0.15% (low-salt) during gestation and either 0.15% or 2.0% (high-salt) NaC1 diets after parturition. Mature DS/JR and DR/JR rats were maintained on either 0.15% or 2.0% NaC1 diets after weaning and studied at 8 to 9 weeks of age. High-salt diet raised blood pressure (BP) and reduced glomerular filtration rate (GFR) and renal blood flow (RBF) in mature DS/JR rats, but had no effect on BP, GFR and RBF in mature DR/JR rats. In immature DS/JR and DR/JR animals, high-salt intake resulted in poor growth with reductions in GFR and RBF in the DS/JR group. The response to acute volume expansion, (5% body weight physiologic saline infusion) differed among the groups. Mature rats all vasodilated while immature high-salt DS/JR did not, and immature low-salt DS/JR vasoconstricted. These studies demonstrated that both mature and immature DS/JR rats evidence abnormal responses to acute and chronic salt loading. Early exposure to high-salt intake affects the maturation of renal function in the DS/JR group. An enhanced vascular sensitivity to sodium is present at critical periods of postnatal development in DS/JR rats.