Microporous P-doped carbon spheres sensory electrode for voltammetry and amperometry adrenaline screening in human fluids
Microporous P-doped carbon spheres sensory electrode for voltammetry and amperometry adrenaline screening in human fluids
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DOI：
10.1007/s00604-021-04782-5
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发表时间：
2021-03
影响因子：
5.7
通讯作者：
Mohammed Y. Emran;M. Shenashen;S. El‐Safty;A. Reda;M. Selim
中科院分区：
文献类型：
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作者：
Mohammed Y. Emran;M. Shenashen;S. El‐Safty;A. Reda;M. Selim
设计了一种基于电化学传感器的磷掺杂微孔碳球结构（P-MCSs），用于人血清选择性肾上腺素（ADR）信号传导。P-MCS电极传感器具有非均匀的表面排列，包括具有开孔和中/宏观凹槽的多种多孔尺寸，粗糙的表面曲率以及具有相互连接和共轭微球的整体形貌。此外，P原子掺杂的石墨碳形成了高活性中心，增加了电极表面的电荷迁移率，产生了丰富的易于功能化的活性中心，并诱导与ADR分子的结合。所设计的P-MCS电极对ADR具有超灵敏的监测效果，检测限低至0.002 μM，灵敏度高至4330 μA μM−1cm−2。此外，还采用了方波伏安法（SWV）和计时安培法（CA）两种电化学技术；这些技术具有高稳定性、快速响应和0.01 ~ 6 μM宽线性范围。基于P-MCSs的传感试验提供了活性界面表面与adr结合位点形成的证据，高电子扩散，以及伴随着/没有球体平面的重靶负载。因此，P-MCSs可用于人血清中ADR的常规监测，提供快速响应，并且需要极低浓度的高度经济的材料。摘要基于p掺杂碳球（P-MCS）的电极表面调制具有高的电化学活性，具有快速电荷传输、多扩散活性中心、高ADR负载和易于在其表面进行分子/电子扩散。P-MCS可灵敏、选择性地检测人体液中的ADR，可用于阿尔茨海默病等神经疾病的临床研究。
An electrochemical sensor-based phosphorus-doped microporous carbon spheroidal structures (P-MCSs) has been designed for selective adrenaline (ADR) signaling in human blood serum. The P-MCS electrode sensor is built with heterogeneous surface alignments including multiple porous sizes with open holes and meso-/macro-grooves, rough surface curvatures, and integral morphology with interconnected and conjugated microspheres. In addition, the P atom-doped graphitic carbon forms highly active centers, increases charge mobility on the electrode surface, creates abundant active centers with facile functionalization, and induces binding to ADR molecules. The designed P-MCS electrode exhibits ultrasensitive monitoring of ADR with a low detection limit of 0.002 μM and high sensitivity of 4330 μA μM−1cm−2. In addition, two electrochemical techniques, namely, square wave voltammetry (SWV) and chronoamperometry (CA), were used; these techniques achieve high stability, fast response, and a wide linear range from 0.01 to 6 μM. The sensing assays based on P-MCSs provide evidence of the formation of active interfacial surface-to-ADR binding sites, high electron diffusion, and heavy target loads along with/without a plane of spheroids. Thus, P-MCSs can be used for the routine monitoring of ADR in human blood serum, providing a fast response, and requiring highly economical materials at extremely low concentrations.Graphical abstractElectrode surface modulation based on P-doped carbon spheres (P-MCS) exhibits high electrochemical activity with fast charge transport, multi-diffusible active centers, high loading of ADR, and facile molecular/electron diffusion at its surface. The P-MCS sensitively and selectively detects the ADR in human fluids and can be used for clinical investigation of some neuronal diseases such as Alzheimer diseases.