Immunohistochemical distribution of s‐100 protein in tumors and tumor‐like lesions of bone and cartilage
Immunohistochemical distribution of s‐100 protein in tumors and tumor‐like lesions of bone and cartilage
复制标题
s-100蛋白在骨和软骨肿瘤及肿瘤样病变中的免疫组织化学分布
作者：
K. Okajima;I. Honda;T. Kitagawa
使用抗生物素蛋白-生物素-过氧化物酶复合物（ABC）免疫染色法检查骨和软骨的各种肿瘤和肿瘤样病变的S-100蛋白。在内生软骨瘤、骨软骨瘤和软骨肉瘤的分化良好的软骨细胞以及正常骺软骨中发现了对S-100蛋白最强烈的反应性。S-100蛋白在成软骨细胞瘤的多角形间质细胞和软骨细胞以及间叶性软骨肉瘤的软骨细胞中均呈阳性表达。在骨肉瘤中，不仅成软骨细胞区，而且成骨细胞区也显示阳性细胞。嗜酸性肉芽肿的网状组织细胞和脉络膜细胞对S-100蛋白呈阳性。本研究得出三个主要结论：（1）S-100蛋白可作为软骨起源和分化、脊索起源和T区组织细胞起源的肿瘤的标志物;（2）通过ABC检测S-100蛋白，可将软骨母细胞瘤与其他组织学上易混淆的巨细胞病变区分开来;（3）S-100蛋白不仅与软骨肿瘤的钙化有关，而且与骨肉瘤的钙化有关。
Various tumors and tumor‐like lesions of bone and cartilage were examined for S‐100 protein using the avidine‐biotin‐peroxidase complex (ABC) immunostaining method. The most intense reactivity for S‐100 protein was found in well‐differentiated chondrocytes of enchondromas, osteochondromas and chondrosarcomas, and in normal epiphyseal cartilage. S‐100 protein was positive in both polygonal stromal cells and chondrocytes of chondroblastomas and in chondrocytes of mesenchymal chondrosarcoma. In osteosarcomas not only chondroblastic areas but also osteoblastic areas showed positive cells. Reticulum histiocytic cells of eosinophilic granulomas and chordoma cells were positive for S‐100 protein. The study yielded three main conclusions: (1) S‐100 protein could be the marker for tumors of cartilaginous origin and differentiation, notochord origin, and T‐zone histiocyte origin; (2) chondroblastoma can be distinguished from other histologically confusing giant cell lesions by using ABC to detect S‐100 protein; and (3) S‐100 protein has some relationship with tumoral calcification not only in cartilaginous tumors but also in osteosarcoma.