Identification of an independent autophagy-gene prognostic index for papillary renal cell carcinoma.
Identification of an independent autophagy-gene prognostic index for papillary renal cell carcinoma.
复制标题
乳头状肾细胞癌独立自噬基因预后指标的鉴定
DOI：
10.21037/tau-20-906
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发表时间：
2020-10
影响因子：
2
通讯作者：
Qin C
中科院分区：
文献类型：
--
作者：
Wei X;Wang W;Wang H;Wang Y;Wang Y;Li G;Ji C;Ren X;Song N;Qin C
背景自噬是一种重要的分解代谢过程，在维持细胞内环境稳定和应激状态下细胞活力方面起着重要作用。自噬失调与多种疾病有关。我们研究的目的是开发一个乳头状肾细胞癌（RCC）的预后标志。方法首先，通过高通量测序和大规模数据库，对40个自噬相关差异表达基因进行分析。然后，进行功能富集分析以探索这些ARG的生物学属性。考克斯比例风险回归分析提示4种ARG（P4HB、BIRC 5、NGR 1和PRKN）与总生存期显著相关。因此，我们得到了具有预后价值的基因。最后，构建预后指数（PI）。结果在确定了4个ARG后，我们分析了我们的风险特征。根据我们制定的PI，乳头状肾细胞癌患者分为高风险和低风险组。高危患者的OS明显短于低危患者（P<0.001），高分患者的死亡率高于低分患者。此外，我们还探讨了4种ARG与临床参数之间的关系，发现P4HB、BIRC 5和NGR 1的表达与临床病理特征相关。结论四基因标记是一个独立的预后因子，可作为判断乳头状肾细胞癌预后的新指标。
Background Autophagy was a significant catabolic process which played a critical role in the maintenance of cellular homeostasis and viability in a stressed state. The dysregulation of autophagy was correlated with various diseases. The aim of our study was to develop a prognostic signature for papillary renal cell carcinoma (RCC). Methods First, 40 differently expressed genes related with autophagy (ARGs) were examined via high-throughput sequencing and large-scale databases. Then, functional enrichment analysis was performed to explore the biological attributes of these ARGs. The Cox proportional hazard regression hinted that four ARGs (P4HB, BIRC5, NGR1 and PRKN) were significantly correlated with overall survival (OS). Thus, we got genes with prognostic value. Finally, a prognostic index (PI) was constructed. Results After identifying the 4 ARGs, we profiled our risk signature. Based on the PI we developed, papillary RCC patients were stratified into high-risk and low-risk groups. High-risk patients had significant shorter OS than low-risk patients (P<0.001) and the mortality of high scoring patients was higher than low scoring patients. Additionally, we explored the relationship between the 4 ARGs and clinical parameters and found that the expression of P4HB, BIRC5 and NGR1 was correlated with clinicopathological features. Conclusions Our study suggested that the four-gene signature was an independent prognostic factor which could act as a novel indicator for the prognosis of papillary RCC.
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