Eosinophilic granulomatosis with polyangiitis presenting with multiple intracerebral haemorrhages - A case report.
Eosinophilic granulomatosis with polyangiitis presenting with multiple intracerebral haemorrhages - A case report.
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伴有多发性脑出血的嗜酸性肉芽肿性多血管炎——病例报告。
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
R. Nazir
中科院分区：
文献类型：
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作者：
Z. Ullah;Z. Abideen;R. Shoaib;Arsalan Ahmad;Q. Zaman;R. Nazir
嗜酸性肉芽肿伴发多血管炎，又称Churg-Strauss综合征，是一种全身性多系统血管炎。神经系统受累主要以周围神经系统疾病的形式出现。中枢神经系统受累相对较少见，大多数病例继发于缺血性梗塞。脑内出血是罕见的，通常以单发出血性病变的形式出现。多发性脑内出血非常罕见，医学文献中只有一例记录。在此，我们提出一个中年男性的病例，他以多发性脑内出血、多发性单发性神经炎、肾脏和呼吸道受累以及外周血嗜酸粒细胞增多为主诉。在符合美国风湿病学会的标准后，他被诊断为异常罕见的EGPA合并多发性脑内出血。他接受了静脉注射糖皮质激素和免疫抑制剂的治疗，恢复良好。
Eosinophilic granulomatosis with polyangiitis also known as Churgg-Strauss syndrome is a systemic multi system vasculitis. Neurological involvement is mostly in the form of peripheral nervous system disease. Central nervous system involvement is relatively uncommon with most cases being secondary to ischaemic infarctions. Intra cerebral haemorrhage is rare and is usually in the form of solitary haemorrhagic lesions. Multiple intra cerebral haemorrhages are exceptionally rare with only one case documented in medical literature. Here, we present the case of a middle aged male who presented to us with multiple intra cerebral haemorrhages, mono neuritis multiplex, renal and respiratory tract involvement and peripheral blood eosinophilia. Upon fulfilling the American College of Rheumatology criteria, he was diagnosed as an exceptionally rare case of EGPA with multiple intra cerebral haemorrhages. He was treated with intra venous corticosteroids and immune suppressants, and made a good recovery.