Effect of stress on atopic dermatitis: Investigation in patients after the Great Hanshin Earthquake
Effect of stress on atopic dermatitis: Investigation in patients after the Great Hanshin Earthquake
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DOI：
10.1016/s0091-6749(99)70130-2
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发表时间：
1999-07-01
影响因子：
14.2
通讯作者：
Ichihashi, M
中科院分区：
文献类型：
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作者：
Kodama, A;Horikawa, T;Ichihashi, M
工作背景：虽然多种因素是导致特应性皮炎（AD）的原因，但关于自然灾害引起的应激对AD症状的影响知之甚少。目的：本研究旨在评估应激或创伤对AD症状的影响。1457例AD患者本研究招募了根据日本皮肤病学会标准诊断的745名男性和712名女性患者。这些数据是从经历神户大地震后的AD患者的自填问卷中获得的。采用多因素Logistic回归分析。患者被分为3组：A区，严重损害的建筑物和房屋;区域B，轻度损害;和控制区，没有damage.Results：皮肤症状的加重被发现在38%和34%的患者在A区和B，分别，而类似的加重被认为是在7%的对照患者。在A区和B区，分别有9%和5%的患者症状有所改善，而对照组只有1%。地震分别在A区和B区造成63%和48%的患者压力，但在未受损区域，很少有患者感到压力（19%）。多元Logistic回归分析显示，在这里检查的因素，主观痛苦的因素，是最负责的皮肤症状的恶化（比值比，2.98; 95%置信区间，2.25-3.96）。结论：这里提出的结果强烈表明，由自然灾害造成的压力影响AD症状。
Background: Although a variety of factors are responsible for atopic dermatitis (AD), very little is known about the effect of stress caused by a natural disaster on AD symptoms.Objective: This study was conducted to assess the effect of stress or trauma on the symptoms of AD.Methods: One thousand four hundred fifty-seven patients with AD (745 males and 712 females), diagnosed by using the criteria of the Japanese Dermatology Association, were enrolled in the study. The data were obtained from a self-administered questionnaire given to patients with AD after experiencing the Great Hanshin Earthquake. The data were analyzed by multivariate logistic regression analysis. Patients were divided into 3 groups: area A, severe damage to buildings and houses; area B, mild damage; and control area, no damage.Results: Exacerbation of skin symptoms was found in 38% and 34% of patients in areas A and B, respectively, whereas similar exacerbation was seen in 7% of control patients. Nine percent and 5% of the patients in areas A and B, respectively, showed improvement in their symptoms compared with 1% in the control group, The earthquake caused stress in 63% and 48% of the patients in areas A and B, respectively, but fewer patients felt stress in undamaged areas (19%). Multiple logistic regression analysis revealed that of the factors examined here, subjective distress is the factor that is most responsible for the exacerbation of skin symptoms (odds ratio, 2.98; 95% confidence interval, 2.25-3.96).Conclusion: The results presented here strongly suggest that stress caused by a natural disaster influences AD symptoms.