Contribution of the large hepatic veins to postsinusoidal vascular resistance.
Contribution of the large hepatic veins to postsinusoidal vascular resistance.
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大肝静脉对窦后血管阻力的贡献。
DOI：
10.1152/ajpgi.1992.262.1.g14
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Rothe,CF
中科院分区：
文献类型：
--
作者：
Maass-Moreno,R;Rothe,CF
我们测试了较大的(大于2 mm内径)肝静脉是狗的门静脉到腔静脉压力梯度的主要部位的假设。将双腔导管插入戊巴比妥钠麻醉犬的肝静脉。一个管腔在末端打开，另一个管腔在侧面打开。每根导管都向前推进，直到停止，然后被拔出。门腔压差的87+/-31降至13+/-11%，因为每一口都超过了一个过渡点(TP)。TP的位置取决于导管的直径。门脉内组胺或去甲肾上腺素分别为4和2.6微克·分~(-1)·kg~(-1)体重，仅增加TP上游测得的压力。通过内部有导管的血管流动的数学模型预测，当导管外径与血管内径之比超过约0.6时，阻力显著增加。尸检显示TP上游的比率超过0.6。水力学模型证实，这种影响导致了TP的出现。考虑到近腔静脉压力的深度(11.7厘米)，即使在组胺给药期间，我们也得出结论，犬肝脏的主要压力梯度必须位于大肝静脉的上游。
We tested the hypothesis that the larger (greater than 2 mm ID) hepatic veins are the primary site of the portal-to-caval venous pressure gradient in the dog. Double-lumen catheters were inserted through the caval wall into hepatic veins of pentobarbital sodium-anesthetized dogs. One lumen opened at the end, and the other to the side. Each catheter was advanced until stopped and then it was withdrawn. The pressure at either port dropped from 87 +/- 31 to 13 +/- 11% of the portal-to-caval pressure difference as each moved past a transition point (TP). The location of the TP depended on the catheter diameter. Intraportal histamine or norepinephrine, 4 and 2.6 micrograms.min-1.kg body wt-1 respectively, augmented only the pressure measured upstream to the TP. A mathematical model of flow through a vessel with a catheter inside predicted a marked increase in resistance when the ratio of catheter OD to vessel ID exceeded approximately 0.6. Autopsy revealed ratios greater than 0.6 upstream to the TP. A hydraulic model confirmed that this effect caused the appearance of the TP. Given the depth (11.7 cm) at which near caval pressures could be found, even during histamine administration, we conclude that the major pressure gradients in the canine liver must lie upstream to the large hepatic veins.
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DOI：
10.1016/0006-291x(75)90887-6
发表时间：
1975-01-01
影响因子：
3.1
作者：
HOUSLEY, T;TANZER, ML;GALLOP, PM
通讯作者：
GALLOP, PM
影响因子：
2.9
作者：
M. Yamauchi;E. P. Katz;E. P. Katz;G. Mechanic
通讯作者：
M. Yamauchi;E. P. Katz;E. P. Katz;G. Mechanic
作为胶原蛋白模型的三肽聚合物。
影响因子：
5.6
作者：
Ada Yonath;Wolfie Traub
通讯作者：
Wolfie Traub
关于胶原原纤维中非等价分子间交错状态。
影响因子：
2.9
作者：
E. Golub;E. P. Katz
通讯作者：
E. P. Katz
制备用于蛋白质序列分析的高度纯化的牛胰蛋白酶。
DOI：
--
发表时间：
1976
期刊：
Biochimica et Biophysica Acta
影响因子：
--
作者：
K. Jany;W. Keil;H. Meyer;H. Kiltz
通讯作者：
H. Kiltz