EFFECT OF ARTERIAL ADMINISTRATION OF HIGH-MOLECULAR-WEIGHT ANTI-CANCER AGENT SMANCS WITH LIPID LYMPHOGRAPHIC AGENT ON HEPATOMA - A PRELIMINARY-REPORT
EFFECT OF ARTERIAL ADMINISTRATION OF HIGH-MOLECULAR-WEIGHT ANTI-CANCER AGENT SMANCS WITH LIPID LYMPHOGRAPHIC AGENT ON HEPATOMA - A PRELIMINARY-REPORT
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DOI：
10.1016/0277-5379(83)90028-7
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
YOKOYAMA, I
中科院分区：
文献类型：
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作者：
KONNO, T;MAEDA, H;YOKOYAMA, I
动脉灌注的高分子量的抗肿瘤剂，SMANCS聚（马来酸-苯乙烯）共轭的新制癌素，溶解在脂质淋巴造影剂（碘乙醇）在44例患者大多无法切除的肝癌的临床评价。该治疗方案在治疗和诊断上都表现出显着的优点。显著的抗肿瘤作用显示在降低的血清α-甲胎蛋白水平（86%的病例）和肿瘤大小（95%的病例），以及生存期和组织学表现。CT扫描、X线平片或超声检查的诊断敏感性增加。选择性动脉给药的程序3-4毫克SMANCS在3-4毫升的乙碘油每剂量是简单的，只需要一次，每3-4周。乙碘油和药物在肿瘤中的蓄积选择性比在任何其他组织中更高，并且它们的活性保持超过3周。在这项研究中，只有最小的副作用与SMANCS和乙碘油有关。
A clinical evaluation of arterial infusion of high-MW antitumor agent, SMANCS poly(maleic acid-styrene)-conjugated neocarzinostatin, dissolved in lipid lymphographic agent (ethiodol) in 44 patients with mostly unresectable hepatoma is described. The treatment regimen demonstrated significant merits both therapeutically and diagnostically. Marked antitumor effects were shown in the decreased serum .alpha.-fetoprotein levels (86% of cases) and tumor size (95% of cases), and in survival period and histological findings. There was increased diagnostic sensitivity using CT scan, plain X-rays or ultrasound. The procedure of selective arterial administration of 3-4 mg of SMANCS in 3-4 ml of ethiodol per dose was simple to perform and was required only once every 3-4 wk. Both ethiodol and the drug accumulated more selectively in tumor than in any other tissues and their activity remained for more than 3 wk. Only minimal side-effects were associated with SMANCS and ethiodol during this study.