Passive protective effect of egg-yolk antibodies against enterotoxigenic Escherichia coli K88+ infection in neonatal and early-weaned piglets
Passive protective effect of egg-yolk antibodies against enterotoxigenic Escherichia coli K88+ infection in neonatal and early-weaned piglets
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DOI：
10.1016/s0928-8244(98)00147-3
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发表时间：
1999-04-01
影响因子：
--
通讯作者：
Baidoo, SK
中科院分区：
文献类型：
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作者：
Marquardt, RR;Jin, LZ;Baidoo, SK
用产K88+菌毛大肠杆菌（EscherichiacoliK 88 + MB，马尼托巴，Canada）菌毛抗原免疫母鸡，获得卵黄抗体，观察其保护作用。在一个商业化猪场的3日龄和21日龄仔猪中评价了ETEC的感染性，并在早期断奶仔猪中进行了评价。结果表明，E. 3日龄仔猪经卵黄抗体治疗后24 h，大肠杆菌K88+ MB诱导的腹泻痊愈，而经普通鸡蛋黄粉治疗的仔猪仍继续腹泻，62.5%的仔猪死于严重腹泻。对于21日龄断奶仔猪，那些喂养蛋黄抗体的仔猪在实验期间出现一过性腹泻、阳性体重增加和100%存活，而用安慰剂治疗的对照仔猪出现严重腹泻和脱水，一些仔猪在感染后48小时内死亡。在田间试验中，饲喂蛋黄抗体的14-18日龄断奶仔猪腹泻的发生率和严重程度远低于饲喂含有抗生素的商业饲料的仔猪。这些结果表明，接受蛋黄抗体的新生仔猪和早期断奶仔猪可免受ETEC感染。(C)1999年，欧洲微生物学会联合会。由Elsevier Science B. V.出版，版权所有。
The protective effects of egg-yolk antibodies obtained from hens immunized with fimbrial antigens from a local strain (Escherichia coli K88+ MB, Manitoba, Canada) of K88+ piliated enterotoxigenic E. coli (ETEC) were evaluated in 3- and 21-day-old piglets in which ETEC diarrhea was induced and also in early-weaned piglets in a commercial farm. The results demonstrated that the E. coli K88+ MB-induced diarrhea in 3-day-old piglets was cured 24 h after treating with egg-yolk antibodies while those treated with egg-yolk powder from conventional hens continued to have diarrhea and 62.5% of them died of severe diarrhea. For 21-day-old weaned piglets, those fed egg-yolk antibodies had transient diarrhea, positive body weight gains and 100% survival during the period of the experiment, whereas control piglets that were treated with placebo had severe diarrhea and dehydration and some died within 48 h after infection. In the field trial, the incidence and severity of diarrhea of 14-18-day-old weaned piglets fed egg-yolk antibodies were much lower than in those fed a commercial diet containing an antibiotic. These results indicate that the neonatal and early weaned piglets that received the egg-yolk antibodies were protected against ETEC infection. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.