A Meta-Analysis on the Impact of Alcohol Dependence on Short-Term Resting-State Heart Rate Variability: Implications for Cardiovascular Risk
A Meta-Analysis on the Impact of Alcohol Dependence on Short-Term Resting-State Heart Rate Variability: Implications for Cardiovascular Risk
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DOI：
10.1111/j.1530-0277.2012.01913.x
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发表时间：
2013-01-01
影响因子：
3.2
通讯作者：
Kemp, Andrew H.
中科院分区：
文献类型：
--
作者：
Quintana, Daniel S.;McGregor, Iain S.;Kemp, Andrew H.
背景酒精依赖与心脏事件的可能性增加有关。心率变异性（HRV）的降低可能是将依赖性与这些事件联系起来的一种机制。HRV也可能与不良的社会功能和缺乏冲动控制有关，这在酒精依赖者中很常见。然而，先前关于酒精依赖对HRV影响的研究报告了矛盾的结果，强调了荟萃分析的必要性。方法对酒精依赖人群和非酒精依赖健康对照者的短期HRV进行比较研究，并进行荟萃分析。只有报告无心血管疾病参与者结果的研究才被纳入分析。结果Meta分析基于6篇符合纳入标准的文章，共包括177名酒精依赖参与者和216名非依赖参与者。与非酒精依赖的参与者相比，酒精依赖的参与者显示HRV降低（Hedges' g =-0.6，p > 0.001）。从不同HRV领域获得的汇总效应量之间没有观察到差异（Q = 1.19，p = 0.55）。结论酒精依赖与HRV降低相关，其效应大小为中等。研究结果强调了监测酒精依赖患者心脏病的重要性，并强调了这些患者心血管风险降低策略的必要性。
Background Alcohol dependence is associated with an increased likelihood of cardiac events. Reductions in heart rate variability (HRV) may be one mechanism linking dependence with these events. HRV may also be related to poor social functioning and the lack of impulse control commonly observed in alcohol-dependent individuals. However, prior studies on the impact of alcohol dependence on HRV have reported contradictory findings highlighting the need for a meta-analysis. Methods Studies comparing short-term HRV in alcohol-dependent populations and healthy controls who were nondependent were considered for meta-analysis. Only studies reporting findings from participants without cardiovascular disease were included in the analysis. Results Meta-analyses were based on 6 articles that fulfilled inclusion criteria, comprising a total of 177 alcohol-dependent participants and 216 nondependent participants. Alcohol-dependent participants displayed reduced HRV (Hedges' g = -0.6, p > 0.001) in comparison with nondependent participants. No differences were observed between the summary effect sizes obtained from different HRV domains (Q = 1.19, p = 0.55). Conclusions Alcohol dependence is associated with reduced HRV, an effect associated with a medium effect size. Findings highlight the importance of monitoring alcohol-dependent patients for cardiac disease and emphasize the need for cardiovascular risk reduction strategies in these patients.