Response of thyrotropin-secreting pituitary adenomas to a long-acting somatostatin analogue.
Response of thyrotropin-secreting pituitary adenomas to a long-acting somatostatin analogue.
复制标题
促甲状腺素分泌垂体腺瘤对长效生长抑素类似物的反应。
DOI：
10.1056/nejm198707023170103
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
B. Weintraub
中科院分区：
文献类型：
--
作者：
R. Comi;N. Gesundheit;L. Murray;P. Gorden;B. Weintraub
促甲状腺激素分泌型垂体腺瘤是一种侵袭性、侵袭性肿瘤，对现有的手术和药物治疗反应很差。这些肿瘤不适当地释放促甲状腺激素可导致甲状腺功能亢进。我们用长效生长抑素类似物SMS 201-995治疗了5例促甲状腺激素分泌性垂体腺瘤患者，每8至12小时皮下注射50至100微克。治疗后，5名患者中有4名的促甲状腺激素血清水平显著降低，另外5名患者的另一种肿瘤标志物促甲状腺激素α亚单位水平也降低。在两名甲状腺功能亢进症患者由于生产过量的促甲状腺激素的肿瘤，治疗与生长抑素类似物导致持续甲状腺功能正常状态。1例治疗超过16个月的患者血清促甲状腺激素和碘甲状腺原氨酸水平持续降低。我们的结论是，SMS 201-995是一种有效的手段，控制促甲状腺激素分泌过多和相关的甲状腺功能亢进症，由于促甲状腺激素分泌垂体瘤。
Thyrotropin-secreting pituitary adenomas are aggressive, invasive tumors that respond poorly to available surgical and medical treatments. Inappropriate release of thyrotropin by these tumors can result in hyperthyroidism. We treated five patients who had thyrotropin-secreting pituitary adenomas with the long-acting somatostatin analogue SMS 201-995, which was administered by subcutaneous injection in doses of 50 to 100 micrograms every 8 to 12 hours. Serum levels of thyrotropin were dramatically reduced by treatment in four of the five patients, and levels of another tumor marker, the alpha-subunit of thyrotropin, were reduced in all five. In two patients with hyperthyroidism due to production of excess thyrotropin by the tumor, treatment with the somatostatin analogue resulted in a sustained euthyroid state. One patient who was treated for more than 16 months had a persistent reduction in serum levels of thyrotropin and iodothyronines. We conclude that SMS 201-995 is an effective means of controlling hypersecretion of thyrotropin and the associated hyperthyroidism due to thyrotropin-secreting pituitary tumors.
促甲状腺素 (TSH) 诱发的甲状腺功能亢进症：TSH 对多巴胺及其激动剂的反应。
DOI：
10.1210/jcem-58-2-255
发表时间：
1984
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Sriwatanakul,K;McCormick,K;Woolf,P
通讯作者：
Woolf,P
使用快速、灵敏的免疫放射测定促甲状腺素来区分正常和甲状腺功能亢进受试者。
影响因子：
9.3
作者：
Cobb,WE;Lamberton,RP;Jackson,IM
通讯作者：
Jackson,IM