Developmental regulation of contractile protein genes.
Developmental regulation of contractile protein genes.
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收缩蛋白基因的发育调控。
DOI：
--
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发表时间：
1989
影响因子：
18.2
通讯作者：
L. Kedes
中科院分区：
文献类型：
--
作者：
R. Wade;L. Kedes
肌肉肌节收缩蛋白的发育调节是精心策划的。这些蛋白质在分化过程中一致出现，并积累到化学计量水平，它们的诱导可以在体内和体外进行检测。这些特性使得肌原纤维发生成为一个理想的模型，用于检查在复杂的个体发育事件中协调基因的表达。近年来，编码许多收缩蛋白的cDNA和基因已从多种物种中分离出来。这允许直接检查的结构元件，是重要的发育调控这些基因，并揭示了contributions的转录和转录后过程的表达。此外，这些研究提供了有关反式作用因子的见解，这些因子可能介导肌肉特异性基因的协调表达。从收缩蛋白基因的克隆中获得的知识是本文的重点。由于篇幅所限，本文主要集中于哺乳动物收缩蛋白基因的研究，但也考虑了其他脊椎动物收缩蛋白基因的一些特别相关的研究。
The developmental regulation of the contractile proteins of the muscle sarco mere is well orchestrated. The proteins appear in concert during differentia tion and accumulate to stoichiometric levels, and their induction can be examined both in vivo and in vitro. These properties make myofibrillogenesis an ideal model for the examination of coordinate gene expression during a complex ontogenetic event. In recent years, cDNAs and genes encoding many of the contractile proteins have been isolated from a variety of species. This has permitted direct examination of the structural elements that are important for the developmental regulation of these genes and has revealed the contribu tions of both transcriptional and posttranscriptional processes to their expres sion. In addition, such studies have provided insights about trans-acting factors that may mediate the coordinate expression of muscle-specific genes. The knowledge gained from the cloning of contractile protein genes is the focus of this review. Because of space limitations, we concentrate on the study of mammalian contractile protein genes, but we also consider some particularly relevant studies of contractile protein genes from other vertebrate speCIes.
选择性剪接在人类慢骨骼肌钙蛋白 T 的重要功能域中产生变异。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Gahlmann,R;Troutt,AB;Wade,RP;Gunning,P;Kedes,L
通讯作者：
Kedes,L
肌球蛋白的分子遗传学。
影响因子：
16.6
作者：
EmersonJr,CP;Bernstein,SI
通讯作者：
Bernstein,SI